Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly

Valassi, Elena; García-Giralt, Natalia; Malouf Sierra, Jorge; Crespo, Iris; Llauger, Jaume; Diez-Perez, Adolfo; Webb, Susan M.

Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly

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dc.contributor.author Valassi, Elena
dc.contributor.author García-Giralt, Natalia
dc.contributor.author Malouf Sierra, Jorge
dc.contributor.author Crespo, Iris
dc.contributor.author Llauger, Jaume
dc.contributor.author Diez-Perez, Adolfo
dc.contributor.author Webb, Susan M.
dc.date.accessioned 2019-04-08T07:27:29Z
dc.date.available 2019-04-08T07:27:29Z
dc.date.issued 2019
dc.description.abstract Background Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated with persistent impairment of trabecular microstructure leading to increased risk of vertebral fractures. Circulating miRNAs modulate the activity of osteoblasts and osteoclasts, and may be potential biomarkers of osteoporosis. Aims Identify differentially expressed miRNAs in the serum of patients with controlled ACRO vs controls and correlate miRNA levels with both biochemical and structural bone parameters. Patients and methods Twenty-seven patients with controlled ACRO (11 males, 16 females; mean age, 48 ± 5 years; BMI, 28 ± 4 kg/m2) and 27 age-, gender- and BMI-matched controls were recruited. Areal BMD at lumbar spine and femur, and trabecular bone score were assessed; volumetric BMD was measured by quantitative computed tomography QCT-Pro (Mindways). Twenty miRNAs, chosen by their putative role in bone, were quantified in serum using real-time qPCR. Results In ACRO patients, miR-103a-3p and miR-191-5p were found overexpressed, whereas miR-660-5p was underexpressed (P < 0.001). miR-103a-3p levels were negatively associated with both trabecular vBMD at trochanter and serum osteoprotegerin concentrations (P < 0.05) and positively with vitamin D concentrations (P < 0.01) and total cross-sectional area of the femoral neck (P < 0.05). miR-660-5p levels were correlated with both trabecular vBMD at trochanter and OPG concentrations (P < 0.05), but were negatively associated with vitamin D levels (P < 0.05). A negative correlation between miR-103-a-3p and miR-660-5p was found in both groups (P < 0.001). Conclusions Circulating miR-103a-3p and miR-660-5p are differentially expressed in controlled ACRO patients and associated with bone structural parameters. miRNAs may be one of the mechanisms involved in the pathogenesis of bone disease and could be used as biomarkers in ACRO patients.
dc.format.mimetype application/pdf
dc.identifier.citation Valassi E, García-Giralt N, Malouf J, Crespo I, Llauger J, Díez-Pérez A. et al. Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly. Endocr Connect. 2019 Jan 1;8(1):39-49. DOI: 10.1530/EC-18-0482
dc.identifier.doi http://dx.doi.org/10.1530/EC-18-0482
dc.identifier.issn 2049-3614
dc.identifier.uri http://hdl.handle.net/10230/37051
dc.language.iso eng
dc.publisher BioScientifica
dc.relation.ispartof Endocrine Connections. 2019 Jan 1;8(1):39-49
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keyword Acromegaly
dc.subject.keyword MicroRNAs
dc.subject.keyword Volumetric bone mineral density
dc.subject.other Acromegàlia
dc.title Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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