Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Postema, Merel C.
• dc.contributor.author Vilarroya, Óscar
• dc.contributor.author Francks, Clyde
• dc.date.accessioned 2021-06-30T07:46:40Z
• dc.date.available 2021-06-30T07:46:40Z
• dc.date.issued 2021
• dc.description.abstract Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
• dc.format.mimetype application/pdf
• dc.identifier.citation Postema MC, Hoogman M, Ambrosino S, Asherson P, Banaschewski T, Bandeira CE et al. Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. J Child Psychol Psychiatry. 2021;62(10):1202-19. DOI: 10.1111/jcpp.13396
• dc.identifier.doi http://dx.doi.org/10.1111/jcpp.13396
• dc.identifier.issn 0021-9630
• dc.identifier.uri http://hdl.handle.net/10230/48014
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof J Child Psychol Psychiatry. 2021;62(10):1202-19
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/728018
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/643051
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32362
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/278948
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847818
• dc.rights © 2021 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Attention-deficit
• dc.subject.keyword Brain asymmetry
• dc.subject.keyword Brain laterality
• dc.subject.keyword Hyperactivity disorder
• dc.subject.keyword Large-scale data
• dc.subject.keyword Structural MRI
• dc.title Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion