Characterizing the adult exposome in men and women from the general population: results from the EHES-LUX study
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- dc.contributor.author Ruiz Castell, María de la Concepción, 1981-
- dc.contributor.author Le Coroller, Gwenaëlle
- dc.contributor.author Pexaras, Achilleas
- dc.contributor.author Ciprián, Giovana M.
- dc.contributor.author Fagherazzi, Guy
- dc.contributor.author Bohn, Torsten
- dc.contributor.author Maitre, Léa
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Appenzeller, Brice M. R.
- dc.date.accessioned 2023-05-23T10:33:42Z
- dc.date.available 2023-05-23T10:33:42Z
- dc.date.issued 2023
- dc.description.abstract Throughout life individuals are exposed to a large array of diverse environmental exposures (exposome). Hair analyses can assess chronic exposure to a large number of chemicals with less intra-variability than urine and blood. This is essential for studies that aim to achieve a global vision of the exposome. We aimed at characterizing the adult exposome by describing 175 environmental exposures and correlation patterns between and within exposure groups. A subsample of participants of the European Health Examination Survey, covering information on exposure to chemical pollutants in hair samples, were included in the present analysis (N = 442). Concentrations of micronutrients, lifestyle, home environment and socioeconomic information completed the exposome description and were obtained through blood analyses and questionnaires. We detected 29 persistent and non-persistent chemical pollutants in more than 70% of hair samples. Compared to women, men had higher concentrations of pesticides, lower concentrations of micronutrients (with the exception of vitamin A), and presented higher alcohol consumption. Across all exposures, a low median absolute correlation was found, 0.05 (5th − 95th centiles = 0.10, 0.20). We observed higher correlations and median correlations within exposure groups than between groups of exposure. The highest median correlation was observed between plasticizers (bisphenol A and S) in both men (0.50) and women (0.31). A 70% and 95% of cumulative variance was explained by 37 and 73 principal components respectively. We found a wide range of chemical exposures in hair samples of men and women. The adult exposome was complex and multidimensional. Future exposome studies should include hair as a matrix for characterizing exposure to multiple environmental chemicals.
- dc.format.mimetype application/pdf
- dc.identifier.citation Ruiz-Castell M, Le Coroller G, Pexaras A, Ciprián GM, Fagherazzi G, Bohn T, et al. Characterizing the adult exposome in men and women from the general population: results from the EHES-LUX study. Environment International. 2023 Mar;173:107780. DOI: 10.1016/j.envint.2023.107780
- dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2023.107780
- dc.identifier.issn 0160-4120
- dc.identifier.uri http://hdl.handle.net/10230/56944
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environment International. 2023 Mar;173:107780
- dc.rights © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Exposome
- dc.subject.keyword Pollutants
- dc.subject.keyword Environmental exposures
- dc.subject.keyword Population-based survey
- dc.subject.keyword Hair analyses
- dc.title Characterizing the adult exposome in men and women from the general population: results from the EHES-LUX study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion