Trends in prevalence of diabetes among twin pregnancies and perinatal outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT study

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  • dc.contributor.author Gortazar, Lucía
  • dc.contributor.author Flores-Le-Roux, Juana Antonia
  • dc.contributor.author Benaiges Foix, David
  • dc.contributor.author Sarsanedas Castellanos, Eugènia
  • dc.contributor.author Navarro, Humberto
  • dc.contributor.author Payà Panadés, Antonio
  • dc.contributor.author Mañé, Laura
  • dc.contributor.author Pedro-Botet, Juan Carlos
  • dc.contributor.author Goday Arno, Alberto
  • dc.date.accessioned 2021-09-29T06:38:33Z
  • dc.date.available 2021-09-29T06:38:33Z
  • dc.date.issued 2021
  • dc.description.abstract The aims of our study were to evaluate the trends in the prevalence of diabetes among twin pregnancies in Catalonia, Spain between 2006 and 2015, to assess the influence of diabetes on perinatal outcomes of twin gestations and to ascertain the interaction between twin pregnancies and glycaemic status. A population-based study was conducted using the Spanish Minimum Basic Data Set. Cases of gestational diabetes mellitus (GDM) and pre-existing diabetes were identified using ICD-9-CM codes. Data from 743,762 singleton and 15,956 twin deliveries between 2006 and 2015 in Catalonia was analysed. Among twin pregnancies, 1088 (6.82%) were diagnosed with GDM and 83 (0.52%) had pre-existing diabetes. The prevalence of GDM among twin pregnancies increased from 6.01% in 2006 to 8.48% in 2015 (p < 0.001) and the prevalence of pre-existing diabetes remained stable (from 0.46% to 0.27%, p = 0.416). The risk of pre-eclampsia was higher in pre-existing diabetes (15.66%, p = 0.015) and GDM (11.39%, p < 0.001) than in normoglycaemic twin pregnancies (7.55%). Pre-existing diabetes increased the risk of prematurity (69.62% vs. 51.84%, p = 0.002) and large-for-gestational-age (LGA) infants (20.9% vs. 11.6%, p = 0.001) in twin gestations. An attenuating effect on several adverse perinatal outcomes was found between twin pregnancies and the presence of GDM and pre-existing diabetes. As a result, unlike in singleton pregnancies, diabetes did not increase the risk of all perinatal outcomes in twins and the effect of pre-existing diabetes on pre-eclampsia and LGA appeared to be attenuated. In conclusion, prevalence of GDM among twin pregnancies increased over the study period. Diabetes was associated with a higher risk of pre-eclampsia, prematurity and LGA in twin gestations. However, the impact of both, pre-existing diabetes and GDM, on twin pregnancy outcomes was attenuated when compared with its impact on singleton gestations.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Gortazar L, Flores-Le Roux JA, Benaiges D, Sarsanedas E, Navarro H, Payà A, Mañé L, Pedro-Botet J, Goday A. Trends in prevalence of diabetes among twin pregnancies and perinatal outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT study. J Clin Med. 2021;10(9):1937. DOI: 10.3390/jcm10091937
  • dc.identifier.doi http://dx.doi.org/10.3390/jcm10091937
  • dc.identifier.issn 2077-0383
  • dc.identifier.uri http://hdl.handle.net/10230/48529
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof J Clin Med. 2021;10(9):1937
  • dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Epidemiology
  • dc.subject.keyword Gestational diabetes
  • dc.subject.keyword Perinatal outcomes
  • dc.subject.keyword Pre-existing diabetes
  • dc.subject.keyword Prevalence
  • dc.subject.keyword Trends
  • dc.subject.keyword Twins
  • dc.title Trends in prevalence of diabetes among twin pregnancies and perinatal outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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