A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles

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• dc.contributor.author Kiewiet, M.B. Gea
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Antó i Boqué, Josep Maria
• dc.contributor.author Valenta, Rudolf
• dc.date.accessioned 2023-05-17T05:47:20Z
• dc.date.available 2023-05-17T05:47:20Z
• dc.date.issued 2023
• dc.description.abstract Background: Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy. Methods: Immunoglobulin E (IgE) sensitization profiles were determined in more than 2800 sera from children in nine population-based cohorts in different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB (the United Kingdom), GINIplus (Germany)], and south [INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)] using the MeDALL-allergen chip. Results: Sensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5-sensitization dominated in North and West/Central Europe. Conclusion: We show regional, exposome- and climate-dependent differences in molecular IgE-reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine-based approaches for treatment and prevention of allergy.
• dc.description.sponsorship The study was supported by the European FP7-program MeDALL, the Danube Allergy Research Cluster by the Country of Lower Austria, the Swedish Research Council, The Region Stockholm (ALF project), The Swedish Asthma and Allergy Association's Research Foundation, The Swedish Cancer and Allergy Foundation, The King Gustaf V 80th Birthday Foundation, The Swedish Heart-Lung Foundation, The Hesselman Foundation, by the European Commission, by Mead Johnson, Evansville, Indiana, USA, by Nestle, Vevey, Vaud, Switzerland, by a Wellcome programme grant [WT223601/Z/21/Z: Age of Wonder, a UK Medical Research Council (MRC) and UK Economic and Social Science Research Council (ESRC) grant: MR/N02439/1 and by the special program (Programmi speciali-Art. 12 bis, comma 6 D.lgs.229/99 Sanitaria e della Vigilanza sugli Enti)] funded by the Italian Ministry of Health.
• dc.format.mimetype application/pdf
• dc.identifier.citation Kiewiet MBG, Lupinek C, Vrtala S, Wieser S, Baar A, Kiss R, et al. A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles. Allergy. 2023 Jul;78(7):2007-18. DOI: 10.1111/all.15689
• dc.identifier.doi http://dx.doi.org/10.1111/all.15689
• dc.identifier.issn 0105-4538
• dc.identifier.uri http://hdl.handle.net/10230/56845
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Allergy. 2023 Jul;78(7):2007-18
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.rights © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Europe
• dc.subject.keyword IgE reactivity
• dc.subject.keyword MeDALL chip
• dc.subject.keyword Allergen molecules
• dc.subject.keyword Exposome
• dc.subject.keyword Sensitization profile
• dc.title A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion