Damage-responsive elements in Drosophila regeneration

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Vizcaya-Molina, Elena
  • dc.contributor.author Klein, Cecilia C.
  • dc.contributor.author Serras Rigalt, Florenci
  • dc.contributor.author Mishra, Rakesh K.
  • dc.contributor.author Guigó Serra, Roderic
  • dc.contributor.author Corominas Guiu, Montserrat
  • dc.date.accessioned 2019-05-03T07:53:50Z
  • dc.date.available 2019-05-03T07:53:50Z
  • dc.date.issued 2018
  • dc.description.abstract One of the most important questions in regenerative biology is to unveil how and when genes change expression and trigger regeneration programs. The resetting of gene expression patterns during response to injury is governed by coordinated actions of genomic regions that control the activity of multiple sequence-specific DNA binding proteins. Using genome-wide approaches to interrogate chromatin function, we here identify the elements that regulate tissue recovery in Drosophila imaginal discs, which show a high regenerative capacity after genetically induced cell death. Our findings indicate there is global coregulation of gene expression as well as a regeneration program driven by different types of regulatory elements. Novel enhancers acting exclusively within damaged tissue cooperate with enhancers co-opted from other tissues and other developmental stages, as well as with endogenous enhancers that show increased activity after injury. Together, these enhancers host binding sites for regulatory proteins that include a core set of conserved transcription factors that control regeneration across metazoans.
  • dc.description.sponsorship This project was funded by the following grants: PCIN-2013-048 from the Spanish Ministerio de Economía y Competitividad and the Institució Catalana de Recerca i Estudis Avançats (via an ICREA Academia award) to M.C.; BFU2012-36888 and BFU2015-67623-P from the Spanish Ministerio de Economía y Competitividad to F.S. and M.C.; the European Research Council/European Community's Seventh Framework Programme grant 294653 RNA-MAPS, the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership, the Spanish Ministry of Economy and Competitiveness (MEC) “Centro de Excelencia Severo Ochoa,” and the CERCA Programme / Generalitat de Catalunya to R.G.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Vizcaya-Molina E, Klein CC, Serras F, Mishra RK, Guigó R, Corominas M. Damage-responsive elements in Drosophila regeneration. Genome Res. 2018;28(12):1852-66. DOI: 10.1101/gr.233098.117
  • dc.identifier.doi http://dx.doi.org/10.1101/gr.233098.117
  • dc.identifier.issn 1088-9051
  • dc.identifier.uri http://hdl.handle.net/10230/37169
  • dc.language.iso eng
  • dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
  • dc.relation.ispartof Genome Research. 2018;28(12):1852-66
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-36888
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-67623-P
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/294653
  • dc.rights © 2018 Vizcaya-Molina et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.title Damage-responsive elements in Drosophila regeneration
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Center for Genomic Regulation (CRG))
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)