Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial

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• dc.contributor.author Ruiz-Bustillo, Sonia
• dc.contributor.author Ivern Díaz, Consol
• dc.contributor.author Badosa Marcé, Neus
• dc.contributor.author Farré López, Núria
• dc.contributor.author Marco Navarro, Ester
• dc.contributor.author Bruguera-Cortada, Jordi
• dc.contributor.author Cladellas Capdevila, M.Mercedes
• dc.contributor.author Enjuanes Grau, Cristina
• dc.contributor.author Cainzos-Achirica, Miguel
• dc.contributor.author Marti-Almor, Julio
• dc.contributor.author Comín Colet, Josep
• dc.date.accessioned 2019-12-20T08:26:42Z
• dc.date.available 2019-12-20T08:26:42Z
• dc.date.issued 2019
• dc.description.abstract Background and aims: Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an intensive lipid-lowering intervention, coordinated by nurses and implemented after hospital discharge, in patients hospitalized for an ischaemic heart disease event. Methods: Randomized controlled trial, in which a nurse-led intervention including periodic follow-up, serial lipid level controls, and subsequent optimization of lipid-lowering therapy, if appropriate, was compared with standard of care alone in terms of serum lipid-level control at six months after discharge. Results: The nurse-led intervention was associated with an improved management of low-density lipoprotein (LDL) cholesterol levels compared with standard of care alone: LDL cholesterol levels ⩽100 mg/dL were achieved in 97% participants in the intervention arm as compared with 67% in the usual care arm ( p value <0.001), the LDL cholesterol ⩽70 mg/dL target recommended by the 2016 European Society of Cardiology guidelines was achieved in 62% vs. 37% participants ( p value 0.047) and the LDL cholesterol reduction of ⩾50% recommended by the American College of Cardiology/American Heart Association in 2013 was achieved in 25.6% of participants in the intervention arm as compared with 2.6% in the usual care arm ( p value 0.007). The intervention was also associated with improved blood pressure control among individuals with hypertension. Conclusions: Our findings highlight the opportunity that nurse-led, intensive, post-discharge follow-up plans may represent for achieving LDL cholesterol guideline-recommended management objectives in patients with ischaemic heart disease. These findings should be replicated in larger cohorts.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ruiz-Bustillo S, Ivern C, Badosa N, Farre N, Marco E, Bruguera J. et al. Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial. Eur J Cardiovasc Nurs. 2019 Jun;18(5):366-374. DOI 10.1177/1474515119831511
• dc.identifier.doi http://dx.doi.org/10.1177/1474515119831511
• dc.identifier.issn 1474-5151
• dc.identifier.uri http://hdl.handle.net/10230/43220
• dc.language.iso eng
• dc.publisher SAGE Publications
• dc.rights Ivern Díaz, Consol; Badosa Marcé, Neus; Farré López, Núria; Marco Navarro, Ester; Bruguera-Cortada, Jordi; Cladellas Capdevila, M.Mercedes. Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial. Eur J Cardiovasc Nurs. 2019 Jun;18(5):366-374. Copyright © 2019. DOI: 10.1177/1474515119831511.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Nurse-led intervention
• dc.subject.keyword Acute coronary syndrome
• dc.subject.keyword Cholesterol
• dc.subject.keyword Schaemic heart disease
• dc.subject.keyword Lipids
• dc.subject.keyword Secondary prevention
• dc.subject.keyword Statins
• dc.title Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion