The pathways of secretory cargo export at the endoplasmic reticulum
Full item page Simple item page
- dc.contributor.author Malhotra, Vivek
- dc.date.accessioned 2025-05-15T06:55:37Z
- dc.date.available 2025-05-15T06:55:37Z
- dc.date.issued 2025
- dc.description.abstract Palade's original model proposed that secretory cargo is transported between stable compartments via vesicles. However, recent findings challenge this view, suggesting that secretory pathway compartments are dynamic, with cargo itself dictating whether transfer occurs via vesicles or through the continuity and maturation of compartmental structures. At the heart of this process is TANGO1, a key component of a molecular machine that works in concert with COPII proteins to construct export routes tailored to the size and quantity of secretory cargo.
- dc.description.sponsorship I extend my heartfelt gratitude to Jeremy Thorner and Ishier Raote for their invaluable assistance in refining this text. I thank Agustin Lujan (Malhotra Lab, CRG) for providing Fig. 1 in this document. I acknowledge financial support from the following sources: Ministerio de Economía y Competitividad (IJCSEV-2012-0208, BFU2013-649 44188-P, and CSD2009-00016 to V.M.) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 951146).
- dc.format.mimetype application/pdf
- dc.identifier.citation Malhotra V. The pathways of secretory cargo export at the endoplasmic reticulum. Nat Commun. 2025 Mar 3;16(1):2138. DOI: 10.1038/s41467-025-57408-2
- dc.identifier.doi http://dx.doi.org/10.1038/s41467-025-57408-2
- dc.identifier.issn 2041-1723
- dc.identifier.uri http://hdl.handle.net/10230/70399
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Nat Commun. 2025 Mar 3;16(1):2138
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/951146
- dc.rights © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Cell biology
- dc.subject.keyword Membrane trafficking
- dc.title The pathways of secretory cargo export at the endoplasmic reticulum
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion