Eye movement desensitization and reprocessing therapy versus supportive therapy in affective relapse prevention in bipolar patients with a history of trauma: study protocol for a randomized controlled trial

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• dc.contributor.author Moreno Alcázar, Anaca
• dc.contributor.author Radua, Joaquimca
• dc.contributor.author Landín-Romero, Ramonca
• dc.contributor.author Blanco, Lauraca
• dc.contributor.author Madre, Mercèca
• dc.contributor.author Reinares, Mariaca
• dc.contributor.author Comes, Mercèca
• dc.contributor.author Jiménez, Estherca
• dc.contributor.author Crespo, Jose Manuelca
• dc.contributor.author Vieta, Eduardca
• dc.contributor.author Pérez Solá, Victorca
• dc.contributor.author Novo Navarro, Maria Patriciaca
• dc.contributor.author Doñate Font, Martaca
• dc.contributor.author Cortizo Vidal, Rominaca
• dc.contributor.author Valiente Gómez, Aliciaca
• dc.contributor.author Lupo, Walterca
• dc.contributor.author McKenna, Peter J.ca
• dc.contributor.author Pomarol-Clotet, Edithca
• dc.contributor.author Amann, Benedikt Lorenzca
• dc.date.accessioned 2018-03-12T08:35:05Z
• dc.date.available 2018-03-12T08:35:05Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: Up to 60% of patients with bipolar disorder (BD) have a history of traumatic events, which is associated with greater episode severity, higher risk of comorbidity and higher relapse rates. Trauma-focused treatment strategies for BD are thus necessary but studies are currently scarce. The aim of this study is to examine whether Eye Movement Desensitization and Reprocessing (EMDR) therapy focusing on adherence, insight, de-idealisation of manic symptoms, prodromal symptoms and mood stabilization can reduce episode severity and relapse rates and increase cognitive performance and functioning in patients with BD. METHODS/DESIGN: This is a single-blind, randomized controlled, multicentre trial in which 82 patients with BD and a history of traumatic events will be recruited and randomly allocated to one of two treatment arms: EMDR therapy or supportive therapy. Patients in both groups will receive 20 psychotherapeutic sessions, 60 min each, during 6 months. The primary outcome is a reduction of affective episodes after 12 and 24 months in favour of the EMDR group. As secondary outcome we postulate a greater reduction in affective symptoms in the EMDR group (as measured by the Bipolar Depression Rating Scale, the Young Mania Rating Scale and the Clinical Global Impression Scale modified for BD), and a better performance in cognitive state, social cognition and functioning (as measured by the Screen for Cognitive Impairment in Psychiatry, The Mayer-Salovey-Caruso Emotional Intelligence Test and the Functioning Assessment Short Test, respectively). Traumatic events will be evaluated by The Holmes-Rahe Life Stress Inventory, the Clinician-administered PTSD Scale and the Impact of Event Scale. DISCUSSION: The results of this study will provide evidence whether a specific EMDR protocol for patients with BD is effective in reducing affective episodes, affective symptoms and functional, cognitive and trauma symptoms.
• dc.format.mimetype application/pdf
• dc.identifier.citation Moreno-Alcázar A, Radua J, Landín-Romero R, Blanco L, Madre M, Reinares M. et al. Eye movement desensitization and reprocessing therapy versus supportive therapy in affective relapse prevention in bipolar patients with a history of trauma: study protocol for a randomized controlled trial. Trials. 2017 Apr 4;18(1):160. DOI: 10.1186/s13063-017-1910-y
• dc.identifier.doi http://dx.doi.org/10.1186/s13063-017-1910-y
• dc.identifier.issn 1745-6215
• dc.identifier.uri http://hdl.handle.net/10230/34077
• dc.language.iso eng
• dc.publisher BioMed Centralca
• dc.relation.ispartof Trials. 2017 Apr 4;18(1):160
• dc.rights © Moreno Alcázar, Ana;Radua, Joaquim; Landín-Romero, Ramon; Blanco, Laura ; Madre, Mercè ; Reinares, Maria; Comes, Mercè ; Jiménez, Esther ; Crespo, Jose Manuel; Eduard Vieta, Eduard ; Pérez Solá, Victor; Novo Navarro, Maria Patricia; Doñate Font, Marta; Cortizo Vidal, Romina; Valiente Gómez, Alicia; Lupo, Walter ; McKenna, Peter J. ; Pomarol-Clotet, Edith; Amann, Benedikt Lorenz .This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Bipolar disorder
• dc.subject.keyword EMDR therapy
• dc.subject.keyword Psychological trauma
• dc.subject.keyword Supportive therapy
• dc.subject.keyword Treatment
• dc.subject.other Psicosi maniacodepressiva
• dc.title Eye movement desensitization and reprocessing therapy versus supportive therapy in affective relapse prevention in bipolar patients with a history of trauma: study protocol for a randomized controlled trialca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion