Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter
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- dc.contributor.author Kuypers, Kim PC
- dc.contributor.author Torre Fornell, Rafael de la
- dc.contributor.author Farré, Magí
- dc.contributor.author Xicota Vila, Laura, 1987-
- dc.contributor.author de Sousa Fernandes Perna, Elizabeth B.
- dc.contributor.author Theunissen, Eef Lien
- dc.contributor.author Ramaekers, Johannes G.
- dc.date.accessioned 2018-11-19T09:19:22Z
- dc.date.available 2018-11-19T09:19:22Z
- dc.date.issued 2018
- dc.description.abstract MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic variant (‘s-group’) of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are homozygous for the l-allele (‘l-group’). The present study aimed to investigate the role of the 5-HTTLPR polymorphism in MDMA-induced mood effects. Four placebo-controlled, within-subject studies were pooled, including in total 63 polydrug ecstasy users (Ns-group = 48; Nl-group = 15) receiving MDMA 75 mg and placebo on two test days, separated by minimally 7 days. Mood was assessed by means of the Profile of Mood States. Findings showed that MDMA induced –independent of sex- a positive mood state, and as a side effect also increased two negative affect states, anxiety and confusion. Anxiety ratings were higher in the l-group and independent of treatment or sex. Depression ratings were lowered by MDMA in the female l-group. Findings indicate that the MDMA-induced reduction in self-rated depressive feelings is sex- and genotype-dependent, with females homozygous for the l-allele showing this beneficial effect.
- dc.format.mimetype application/pdf
- dc.identifier.citation Kuypers KPC, de la Torre R, Farre M, Xicota L, de Sousa Fernandes Perna EB, Theunissen EL et al. Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter. Sci Rep. 2018;8(1):1061. DOI: 10.1038/s41598-018-19618-1
- dc.identifier.doi http://dx.doi.org/10.1038/s41598-018-19618-1
- dc.identifier.issn 2045-2322
- dc.identifier.uri http://hdl.handle.net/10230/35787
- dc.language.iso eng
- dc.publisher Nature Publishing Group
- dc.relation.ispartof Scientific Reports. 2018;8(1):1061
- dc.rights © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Behavioural genetics
- dc.subject.keyword Social behaviour
- dc.title Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion