Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway
Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway
Citació
- Miller SW, Movsesyan A, Zhang S, Fernández R, Posakony JW. Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway. Elife. 2019; 8. pii: e48115. DOI: 10.7554/eLife.48115
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Resum
Suppressor of Hairless [Su(H)], the transcription factor at the end of the Notch pathway in Drosophila, utilizes the Hairless protein to recruit two co-repressors, Groucho (Gro) and C-terminal Binding Protein (CtBP), indirectly. Hairless is present only in the Pancrustacea, raising the question of how Su(H) in other protostomes gains repressive function. We show that Su(H) from a wide array of arthropods, molluscs, and annelids includes motifs that directly bind Gro and CtBP; thus, direct co-repressor recruitment is ancestral in the protostomes. How did Hairless come to replace this ancestral paradigm? Our discovery of a protein (S-CAP) in Myriapods and Chelicerates that contains a motif similar to the Su(H)-binding domain in Hairless has revealed a likely evolutionary connection between Hairless and Metastasis-associated (MTA) protein, a component of the NuRD complex. Sequence comparison and widely conserved microsynteny suggest that S-CAP and Hairless arose from a tandem duplication of an ancestral MTA gene.Col·leccions
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