Hypofractionated boost after whole breast irradiation in breast carcinoma: chronic toxicity results and cosmesis

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• dc.contributor.author Sanz Latiesas, Javier, 1967-ca
• dc.contributor.author Rodríguez, Nuriaca
• dc.contributor.author Foro Arnalot, Palmiraca
• dc.contributor.author Dengra, Josefaca
• dc.contributor.author Reig, Annaca
• dc.contributor.author Pérez, Paulaca
• dc.contributor.author Membrive, Ismaelca
• dc.contributor.author Ortiz, Anaca
• dc.contributor.author Codinach, Mariaca
• dc.contributor.author Algara López, Manuel-Ignacioca
• dc.date.accessioned 2017-07-05T07:37:46Z
• dc.date.issued 2017
• dc.description.abstract PURPOSE: To evaluate the impact of hypofractionated boost after hypofractionated whole breast irradiation in breast carcinoma. METHODS AND MATERIALS: Patients after breast conservative surgery were treated all time with hypofractionation of 2.67 Gy/day. Whole breast dose was 40.05 Gy followed in case of risk of local relapse by a boost of 16.02 Gy or 8.01 Gy. Acute and chronic toxicity results were evaluated including cosmetic software-assisted assessment and objective evaluation of fibrosis parameters (elasticity and hydration) by means of a skin tester. RESULTS: A total of 362 patients were evaluated. Acute toxicities comprised grade 1 dermatitis in 48.1 %, grade 2 in 44.5 % and grade 3 in 17 patients 4.7 %, respectively. After a median follow-up of 4.5 years, in 308 cases (86.6 %) there was no chronic skin or subcutaneous changes. In the first consecutive 50 patients, measures with skin tester showed no statistical differences in parameters for skin and subcutaneous fibrosis. Cosmetic results were considered excellent and good in 26 and 62 %, respectively. CONCLUSIONS: Boost to tumour bed with hypofractionated doses is well tolerated and acute and chronic toxicities are mild with good cosmetic results. Objective systems are encouraging methods to assess skin quality and cosmesis.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Sanz J, Rodríguez N, Foro P, Dengra J, Reig A, Pérez P. Hypofractionated boost after whole breast irradiation in breast carcinoma: chronic toxicity results and cosmesis. Clin Transl Oncol. 2017 Apr;19(4):464-9. DOI: 10.1007/s12094-016-1548-3
• dc.identifier.doi http://dx.doi.org/10.1007/s12094-016-1548-3
• dc.identifier.issn 1699-048X
• dc.identifier.uri http://hdl.handle.net/10230/32508
• dc.language.iso eng
• dc.publisher Springerca
• dc.relation.ispartof Clinical and Translational Oncology. 2017 Apr;19(4):464-9
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s12094-016-1548-3
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Mama -- Càncer
• dc.subject.other Cirurgia plàstica
• dc.subject.other Toxicologia
• dc.subject.other Radioteràpia
• dc.title Hypofractionated boost after whole breast irradiation in breast carcinoma: chronic toxicity results and cosmesisca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion