Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

Casas, Rosa; Urpi-Sardà, Mireia; Sacanella, Emilio; Arranz, Sara; Corella, Dolores; Castañer, Olga; Lamuela-Raventós, Rosa M.; Salas Salvadó, Jordi; Lapetra, José; Portillo, María P.; Estruch, Ramón

Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

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dc.contributor.author Casas, Rosaca
dc.contributor.author Urpi-Sardà, Mireiaca
dc.contributor.author Sacanella, Emilioca
dc.contributor.author Arranz, Saraca
dc.contributor.author Corella, Doloresca
dc.contributor.author Castañer, Olgaca
dc.contributor.author Lamuela-Raventós, Rosa M.ca
dc.contributor.author Salas Salvadó, Jordica
dc.contributor.author Lapetra, Joséca
dc.contributor.author Portillo, María P.ca
dc.contributor.author Estruch, Ramónca
dc.date.accessioned 2018-06-26T07:42:15Z
dc.date.available 2018-06-26T07:42:15Z
dc.date.issued 2017
dc.description.abstract Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P < 0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P < 0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P < 0.05; both) in the MeDiet+nuts group. Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
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dc.identifier.citation Casas R, Urpi-Sardà M, Sacanella E, Arranz S, Corella D, Castañer O. et al. Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. Mediators Inflamm. 2017;2017:3674390. DOI: 10.1155/2017/3674390
dc.identifier.doi http://dx.doi.org/10.1155/2017/3674390
dc.identifier.issn 0962-9351
dc.identifier.uri http://hdl.handle.net/10230/34967
dc.language.iso eng
dc.publisher Hindawica
dc.relation.ispartof Mediators of Inflammation. 2017;2017:3674390
dc.rights Copyright © 2017 Rosa Casas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Placa ateroscleròtica
dc.subject.other Dieta mediterrània
dc.title Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Developmentca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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