Association of occupational heat exposure and colorectal cancer in the MCC-Spain study

Hinchliffe, Alice; Kogevinas, Manolis; Molina, Antonio J.; Moreno, Víctor; Aragonés, Núria; Castaño Vinyals, Gemma; Jiménez Moleón, José Juan; Gómez-Acebo, Inés; Ederra, María; Amiano, Pilar; Molina-Barceló, Ana; Fernandez-Tardon, Guillermo; Alguacil Ojeda, Juan; Chirlaque, María Dolores; Hernández-Segura, Natalia; Pérez-Gómez, Beatriz; Pollán, Marina; Turner, Michelle C.

doi:http://dx.doi.org/10.5271/sjweh.4082

Association of occupational heat exposure and colorectal cancer in the MCC-Spain study

Citation

Hinchliffe A, Kogevinas M, Molina AJ, Moreno V, Aragonés N, Castaño-Vinyals G, Jiménez Moleón JJ, Gómez Acebo I, Ederra M, Amiano P, Molina-Barceló A, Fernandez-Tardon G, Alguacil J, Chirlaque MD, Hernández-Segura N, Pérez-Gómez B, Pollan M, Turner MC. Association of occupational heat exposure and colorectal cancer in the MCC-Spain study. Scand J Work Environ Health. 2023;49(3):211-21. DOI: 10.5271/sjweh.4082

Abstract

Objective: Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest in potential chronic health effects of occupational heat exposure, including cancer risk. We examined potential associations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case--control study. Methods: We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls. The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupations of participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure and duration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression adjusting for potential confounders. Results: Overall, there was no association of ever, compared with never, occupational heat exposure and CRC (OR 1.09, 95% CI 0.92-1.29). There were also no associations observed according to categories of cumulative exposure or duration, and there was no evidence for a trend. There was no clear association of ever occupational heat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positive associations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI 1.09-3.03) and duration (OR 2.89, 95% CI 1.50-5.59) as well as some evidence for a trend (P<0.05). Conclusion: Overall, this study provides no clear evidence for an association between occupational heat exposure and CRC.