Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C.

Lens, Sabela; Calleja, Jose Luis; Campillo, Ana; Carrión Rodríguez, José Antonio; Broquetas, Teresa; Perello, Christie; de la Revilla, Juan; Mariño, Zoe; Londoño, María-Carlota; Sánchez-Tapias, José Maria; Urbano-Ispizua, Álvaro; Forns, Xavier

Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C.

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dc.contributor.author Lens, Sabelaca
dc.contributor.author Calleja, Jose Luisca
dc.contributor.author Campillo, Anaca
dc.contributor.author Carrión Rodríguez, José Antonioca
dc.contributor.author Broquetas, Teresaca
dc.contributor.author Perello, Christieca
dc.contributor.author de la Revilla, Juanca
dc.contributor.author Mariño, Zoeca
dc.contributor.author Londoño, María-Carlotaca
dc.contributor.author Sánchez-Tapias, José Mariaca
dc.contributor.author Urbano-Ispizua, Álvaroca
dc.contributor.author Forns, Xavierca
dc.date.accessioned 2015-06-08T11:43:03Z
dc.date.available 2015-06-08T11:43:03Z
dc.date.issued 2015
dc.description.abstract elaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin. Pancytopenia due to myelotoxicity caused by these drugs may occur, but severe hematological abnormalities or aplastic anemia (AA) have not been described. We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011. Among 142 cirrhotic patients receiving treatment, 7 cases of severe pancytopenia (5%) were identified and three were consistent with the diagnosis of AA. Mean age was 59 years, five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation. Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy. Three patients had pre-treatment hematological abnormalities related to splenomegaly. In six patients, antiviral treatment was interrupted at the onset of hematological abnormalities. Two patients died due to septic complications and one patient due to acute alveolar hemorrhage. The remaining patients recovered. Severe pancytopenia and especially AA, are not rare during triple therapy with telaprevir in patients with advanced liver disease. Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.ca
dc.description.sponsorship Supported by (in part) Instituto de Salud Carlos III (PI11/01907), Ministerio de Economía y Competitividad, co-funded by Fondo/nEuropeo de Desarrollo Regional, Unión Europea, Una manera de hacer Europa; and Roche Organ Transplantation Research/nFoundation (ROTRF, CI: 442035057) (all to Forns X).
dc.format.mimetype application/pdfca
dc.identifier.citation Lens S, Calleja JL, Campillo A, Carrión JA, Broquetas T, Perello C. et al. Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C. World J Gastroenterol. 2015 May 7;21(17):5421-6. doi: 10.3748/wjg.v21.i17.5421.ca
dc.identifier.doi http://dx.doi.org/10.3748/wjg.v21.i17.5421
dc.identifier.issn 1007-9327
dc.identifier.uri http://hdl.handle.net/10230/23766
dc.language.iso engca
dc.publisher Baishideng Publishing Groupca
dc.relation.ispartof World Journal of Gastroenterology. 2015 May 7;21(17):5421-6
dc.rights This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and/nthe use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ca
dc.subject.other Anèmiaca
dc.subject.other Hepatitis Cca
dc.subject.other Interferóca
dc.title Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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