Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

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• dc.contributor.author Bonkhoff, Anna K.
• dc.contributor.author Jimenez-Conde, Jordi
• dc.contributor.author Roquer, Jaume
• dc.contributor.author Rost, Natalia
• dc.date.accessioned 2022-06-23T06:34:11Z
• dc.date.available 2022-06-23T06:34:11Z
• dc.date.issued 2021
• dc.description.abstract Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Brudfors M et al. Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. Nat Commun. 2021 Jun 2;12(1):3289. DOI: 10.1038/s41467-021-23492-3
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-021-23492-3
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/53575
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Commun. 2021 Jun 2;12(1):3289
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Brain
• dc.subject.keyword Stroke
• dc.title Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion