Specific hippocampal interneurons shape consolidation of recognition memory

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Oliveira da Cruz, Jose F.
• dc.contributor.author Busquets Garcia, Arnau, 1985-
• dc.contributor.author Zhao, Zhe
• dc.contributor.author Varilh, Marjorie
• dc.contributor.author Lavanco, Gianluca
• dc.contributor.author Robin, Laurie
• dc.contributor.author Cannich, Astrid
• dc.contributor.author Julio-Kalajzić, Francisca
• dc.contributor.author Lesté-Lasserre, Thierry
• dc.contributor.author Maître, Marlène
• dc.contributor.author Drago, Filippo
• dc.contributor.author Marsicano, Giovanni
• dc.contributor.author Soria-Gómez, Edgar
• dc.date.accessioned 2021-06-09T07:36:03Z
• dc.date.available 2021-06-09T07:36:03Z
• dc.date.issued 2020
• dc.description.abstract A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB1Rs in D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D1-dependent manner. This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.
• dc.description.sponsorship We thank Delphine Gonzales, Nathalie Aubailly, and the personnel of the Animal Facilities of the NeuroCentre Magendie for mouse care. We thank the Biochemistry Platform of Bordeaux NeuroCampus and the members of Marsicano’s lab for useful discussions. This work was funded by INSERM; the European Research Council (Endofood ERC-2010-StG-260515, CannaPreg ERC-2014-PoC-640923, and MiCaBra ERC-2017-AdG-786467 to G.M.); Fondation pour la Recherche Medicale (FRM; DRM20101220445 to G.M. and DT20160435664 to J.F.O.d.C.); the Human Frontiers Science Program, Region Aquitaine, Agence Nationale de la Recherche (ANR; NeuroNutriSens ANR-13-BSV4-0006, ORUPS ANR-16-CE37-0010-01, and CaCoVi ANR-18-CE16-0001-02 to G.M.); BRAIN ANR-10-LABX-0043 (to G.M.); NIH/NIDA (1R21DA037678-01); the European Regional Development Fund; the European Union Horizon 2020 Research and Innovation Program (grant agreement 686009); French State/Agence Nationale de la Recherche/IdEx (ANR-10-IDEX-03-02), Eu-Fp7 (FP7-PEOPLE-2013-IEF-623638), and MINECO/AEI (RYC-2017-21776) (to A.B.-G.); FRM (ARF20140129235 to L.B.); and Ikerbasque (The Basque Foundation for Science) and MINECO (Ministerio de Economía y Competitividad) PGC2018-093990-A-I00 (MICIU/AEI/FEDER, UE) (to E.S.-G.).
• dc.format.mimetype application/pdf
• dc.identifier.citation Oliveira da Cruz JF, Busquets-Garcia A, Zhao Z, Varilh M, Lavanco G, Bellocchio L, et al. Specific hippocampal interneurons shape consolidation of recognition memory. Cell Rep. 2020 Aug 18; 32(7): 108046. DOI: 10.1016/j.celrep.2020.108046
• dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2020.108046
• dc.identifier.issn 2211-1247
• dc.identifier.uri http://hdl.handle.net/10230/47808
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/686009
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/623638
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC-2017-21776
• dc.rights Copyright © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword CB(1) receptor
• dc.subject.keyword D(1) receptor
• dc.subject.keyword GABA
• dc.subject.keyword Dopamine
• dc.subject.keyword Endocannabinoid system
• dc.subject.keyword Hippocampus
• dc.subject.keyword Interneurons
• dc.subject.keyword Long-term potentiation
• dc.subject.keyword Novel object recognition memory
• dc.title Specific hippocampal interneurons shape consolidation of recognition memory
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion