The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond

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• dc.contributor.author Cavazza, Tommaso, 1985-
• dc.contributor.author Vernos, Isabelle, 1959-
• dc.date.accessioned 2023-11-28T07:09:18Z
• dc.date.available 2023-11-28T07:09:18Z
• dc.date.issued 2016
• dc.description.abstract The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors stabilizes their interaction with the cargo. This basic mechanism linked to the asymmetric distribution of the two nucleotide-bound forms of Ran between the nucleus and the cytoplasm generates a switch like mechanism controlling nucleo-cytoplasmic transport. Since 1999, we have known that after nuclear envelope breakdown (NEBD) Ran and the above transport receptors also provide a local control over the activity of factors driving spindle assembly and regulating other aspects of cell division. The identification and functional characterization of RanGTP mitotic targets is providing novel insights into mechanisms essential for cell division. Here we review our current knowledge on the RanGTP system and its regulation and we focus on the recent advances made through the characterization of its mitotic targets. We then briefly review the novel functions of the pathway that were recently described. Altogether, the RanGTP system has moonlighting functions exerting a spatial control over protein interactions that drive specific functions depending on the cellular context.
• dc.description.sponsorship TC was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the FPI fellowship BES-2010-031355. Work in the Vernos lab was supported by the Spanish ministry grants BFU2009-10202 and BFU2012-37163, co-financed by the European Regional Development Fund (ERDF/FEDER). We also acknowledge support of the Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa 2013-2017,” SEV-2012-0208.
• dc.format.mimetype application/pdf
• dc.identifier.citation Cavazza T, Vernos I. The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond. Front Cell Dev Biol. 2016 Jan 11;3:82. DOI: 10.3389/fcell.2015.00082
• dc.identifier.doi http://dx.doi.org/10.3389/fcell.2015.00082
• dc.identifier.issn 2296-634X
• dc.identifier.uri http://hdl.handle.net/10230/58397
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Cell and Developmental Biology. 2016 Jan 11;3:82
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BES-2010-031355
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-10202
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-37163
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SEV-2012-0208
• dc.rights © 2016 Cavazza and Vernos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Spindle
• dc.subject.keyword RanGTP
• dc.subject.keyword Microtubule
• dc.subject.keyword Cell division
• dc.subject.keyword Importin
• dc.subject.keyword SAF
• dc.subject.keyword Nucleo-cytoplasmic transport
• dc.subject.keyword Exportin
• dc.title The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion