Respiratory muscle senescence in ageing and chronic lung diseases
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- dc.contributor.author Gea Guiral, Joaquim
- dc.contributor.author Ausín Herrero, Pilar, 1974-
- dc.contributor.author Martínez-Llorens, Juana Mª
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2020-10-05T06:08:13Z
- dc.date.available 2020-10-05T06:08:13Z
- dc.date.issued 2020
- dc.description.abstract Ageing is a progressive condition that usually leads to the loss of physiological properties. This process is also present in respiratory muscles, which are affected by both senescent changes occurring in the whole organism and those that are more specific for muscles. The mechanisms of the latter changes include oxidative stress, decrease in neurotrophic factors and DNA abnormalities. Ageing normally coexists with comorbidities, including respiratory diseases, which further deteriorate the structure and function of respiratory muscles. In this context, changes intrinsic to ageing become enhanced by more specific factors such as the impairment in lung mechanics and gas exchange, exacerbations and hypoxia. Hypoxia in particular has a direct effect on muscles, mainly through the expression of inducible factors (hypoxic-inducible factor), and can result in oxidative stress and changes in DNA, decrease in mitochondrial biogenesis and defects in the tissue repair mechanisms. Intense exercise can also cause damage in respiratory muscles of elderly respiratory patients, but this can be followed by tissue repair and remodelling. However, ageing interferes with muscle repair by tampering with the function of satellite cells, mainly due to oxidative stress, DNA damage and epigenetic mechanisms. In addition to the normal process of ageing, stress-induced premature senescence can also occur, involving changes in the expression of multiple genes but without modifications in telomere length.
- dc.format.mimetype application/pdf
- dc.identifier.citation Gea J, Ausín P, Martínez-Llorens JM, Barreiro E. Respiratory muscle senescence in ageing and chronic lung diseases. Eur Respir Rev. 2020; 29(157):200087. DOI: 10.1183/16000617.0087-2020
- dc.identifier.doi http://dx.doi.org/10.1183/16000617.0087-2020
- dc.identifier.issn 0905-9180
- dc.identifier.uri http://hdl.handle.net/10230/45389
- dc.language.iso eng
- dc.publisher European Respiratory Society
- dc.relation.ispartof Eur Respir Rev. 2020; 29(157):200087
- dc.rights Copyright © ERS 2020. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (http://creativecommons.org/licenses/by-nc/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.title Respiratory muscle senescence in ageing and chronic lung diseases
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion