Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model
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- dc.contributor.author Mercader Bigas, Josep Mariaca
- dc.contributor.author Lozano, Juan Joséca
- dc.contributor.author Sumoy Van Dyck, Lauroca
- dc.contributor.author Dierssen, Maraca
- dc.contributor.author Visa, Joanaca
- dc.contributor.author Gratacós Mayora, Mònicaca
- dc.contributor.author Estivill, Xavier, 1955-ca
- dc.date.accessioned 2012-05-31T10:32:50Z
- dc.date.available 2012-05-31T10:32:50Z
- dc.date.issued 2008ca
- dc.description.abstract The anx/anx mouse displays poor appetite and lean appearance and is considered a good model for the study of anorexia nervosa. To identify new genes involved in feeding behavior and body weight regulation we performed an expression profiling in the hypothalamus of the anx/anx mice. Using commercial microarrays we detected 156 differentially expressed genes and validated 92 of those using TaqMan low-density arrays. The expression of a set of 87 candidate genes selected based on literature evidences was also quantified by TaqMan low-density arrays. Our results showed enrichment in deregulated genes involved in cell death, cell morphology and cancer as well as an alteration of several signaling circuits involved in energy balance including neuropeptide Y and melanocortin signaling. The expression profile along with the phenotype led us to conclude that anx/anx mice resemble the anorexia-cachexia syndrome typically observed in cancer, infection with human immunodeficiency virus or chronic diseases, rather than starvation, and that anx/anx mice could be considered a good model for the treatment and investigation of this condition.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacòs M, Estivill X. Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiol. Genomics. 2008;35(3):341-50. DOI: 10.1152/physiolgenomics.90255.2008ca
- dc.identifier.doi http://dx.doi.org/10.1152/physiolgenomics.90255.2008
- dc.identifier.issn 1094-8341ca
- dc.identifier.uri http://hdl.handle.net/10230/16492
- dc.language.iso engca
- dc.publisher American Physiological Societyca
- dc.relation.ispartof Physiological genomics. 2008;35(3):341-50
- dc.rights © 2008, American Physiological Societyca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Cachexia
- dc.subject.keyword Anx/anx
- dc.subject.keyword Anorexia
- dc.subject.keyword Hypothalamus
- dc.subject.keyword Transcriptome
- dc.subject.keyword Feeding regulation
- dc.subject.keyword Chronic disorders
- dc.subject.other Anorèxia nerviosa
- dc.subject.other Trastorns de la conducta alimentària -- Aspectes genètics
- dc.subject.other Trastorns de la conducta alimentària -- Models animals
- dc.title Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse modelca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/submittedVersion