The blood-brain barrier: structure, function and therapeutic approaches to cross it
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- dc.contributor.author Tajes Orduña, Martaca
- dc.contributor.author Ramos Fernández, Eva, 1984-ca
- dc.contributor.author Weng-Jiang, Xianca
- dc.contributor.author Bosch Morató, Mònica, 1986-ca
- dc.contributor.author Guivernau Almazán, Biuse, 1988-ca
- dc.contributor.author Eraso Pichot, Abelca
- dc.contributor.author Salvador, Bertránca
- dc.contributor.author Fernàndez Busquets, Xavierca
- dc.contributor.author Roquer, Jaumeca
- dc.contributor.author Muñoz López, Francisco José, 1964-ca
- dc.date.accessioned 2016-06-09T17:28:04Z
- dc.date.available 2016-06-09T17:28:04Z
- dc.date.issued 2014
- dc.description.abstract The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that interacts directly with astrocytes, neurons and pericytes. It protects the brain from the molecules of the systemic circulation but it has to be overcome for the proper treatment of brain cancer, psychiatric disorders or neurodegenerative diseases, which are dramatically increasing as the population ages. In the present work we have revised the current knowledge on the cellular structure of the BBB and the different procedures utilized currently and those proposed to cross it. Chemical modifications of the drugs, such as increasing their lipophilicity, turn them more prone to be internalized in the brain. Other mechanisms are the use of molecular tools to bind the drugs such as small immunoglobulins, liposomes or nanoparticles that will act as Trojan Horses favoring the drug delivery in brain. This fusion of the classical pharmacology with nanotechnology has opened a wide field to many different approaches with promising results to hypothesize that BBB will not be a major problem for the new generation of neuroactive drugs. The present review provides an overview of all state-of-the-art of the BBB structure and function, as well as of the classic strategies and these appeared in recent years to deliver drugs into the brain for the treatment of Central Nervous System (CNS) diseases.ca
- dc.description.sponsorship This work was supported by the Plan Estatal de I+D+i 2013-2016 and the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación (Grants PI13/00408, PI08/00574 and Red HERACLES RD12/0042/0014 & RD12/0042/0016) and FEDER Funds; Spanish Ministry of Science and Innovation (RD12/0042/0016; BIO2011-25039); Generalitat de Catalunya (SGR09-1369 and SGR-760); and Fundació la Marató de TV3 (100310).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Tajes M, Ramos-Fernández E, Weng-Jiang X, Bosch-Morató M, Guivernau B, Eraso-Pichot A et al. The blood-brain barrier: structure, function and therapeutic approaches to cross it. Molecular membrane biology. 2014;31(5):152-67. DOI: 10.3109/09687688.2014.937468ca
- dc.identifier.doi http://dx.doi.org/10.3109/09687688.2014.937468
- dc.identifier.issn 0968-7688
- dc.identifier.uri http://hdl.handle.net/10230/26886
- dc.language.iso engca
- dc.publisher Taylor & Francis (Routledge)ca
- dc.relation.ispartof Molecular membrane biology. 2014;31(5):152-67
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-25039
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-25039
- dc.rights © Taylor & Francis. This is an electronic version of an article published in Tajes M, Ramos-Fernández E, Weng-Jiang X, Bosch-Morató M, Guivernau B, Eraso-Pichot A et al. The blood-brain barrier: structure, function and therapeutic approaches to cross it. Molecular membrane biology. 2014; 31(5): 152-167. DOI 10.3109/09687688.2014.937468. Molecular membrane biology is available online at: http://www.tandfonline.com/doi/full/10.3109/09687688.2014.937468ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Blood brain barrier
- dc.subject.keyword Drug delivery
- dc.subject.keyword Membrane transport
- dc.subject.other Malalties mentals -- Tractamentca
- dc.title The blood-brain barrier: structure, function and therapeutic approaches to cross itca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca