Precision medicine in neurodegeneration: the IHI-PROMINENT project

Tate, Ashley; Suárez-Calvet, Marc; Ekelund, Mats; Eriksson, Sven; Eriksdotter, Maria; van der Flier, Wiesje M.; Georges, Jean; Kivipelto, Miia; Kramberger, Milica G.; Lindgren, Peter; Gispert López, Juan Domingo; Lötjönen, Jyrki; Persson, Sofie; Pla, Sandra; Solomon, Alina; Thurfjell, Lennart; Wimo, Anders; Winblad, Bengt; Jönsson, Linus; PROMINENT consortium

Precision medicine in neurodegeneration: the IHI-PROMINENT project

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dc.contributor.author Tate, Ashley
dc.contributor.author Suárez-Calvet, Marc
dc.contributor.author Ekelund, Mats
dc.contributor.author Eriksson, Sven
dc.contributor.author Eriksdotter, Maria
dc.contributor.author van der Flier, Wiesje M.
dc.contributor.author Georges, Jean
dc.contributor.author Kivipelto, Miia
dc.contributor.author Kramberger, Milica G.
dc.contributor.author Lindgren, Peter
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author Lötjönen, Jyrki
dc.contributor.author Persson, Sofie
dc.contributor.author Pla, Sandra
dc.contributor.author Solomon, Alina
dc.contributor.author Thurfjell, Lennart
dc.contributor.author Wimo, Anders
dc.contributor.author Winblad, Bengt
dc.contributor.author Jönsson, Linus
dc.contributor.author PROMINENT consortium
dc.date.accessioned 2024-05-14T06:19:00Z
dc.date.available 2024-05-14T06:19:00Z
dc.date.issued 2023
dc.description.abstract Neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly. In Europe, over 14 million people are currently living with dementia, at a cost of over 400 billion EUR annually. Recent advances in diagnostics and approval for new pharmaceutical treatments for Alzheimer's disease (AD), the most common etiology of dementia, heralds the beginning of precision medicine in this field. However, their implementation will challenge an already over-burdened healthcare systems. There is a need for innovative digital solutions that can drive the related clinical pathways and optimize and personalize care delivery. Public-private partnerships are ideal vehicles to tackle these challenges. Here we describe the Innovative Health Initiative (IHI) public-private partnership project PROMINENT that has been initiated by connecting leading dementia researchers, medical professionals, dementia patients and their care partners with the latest innovative health technologies using a precision medicine based digital platform. The project builds upon the knowledge and already implemented digital tools from several collaborative initiatives that address new models for early detection, diagnosis, and monitoring of AD and other neurodegenerative disorders. The project aims to provide support to improvement efforts to each aspect of the care pathway including diagnosis, prognosis, treatment, and data collection for real world evidence and cost effectiveness studies. Ultimately the PROMINENT project is expected to lead to cost-effective care and improved health outcomes.
dc.format.mimetype application/pdf
dc.identifier.citation Tate A, Suárez-Calvet M, Ekelund M, Eriksson S, Eriksdotter M, Van Der Flier WM, et al. Precision medicine in neurodegeneration: the IHI-PROMINENT project. Front Neurol. 2023 Aug 2;14:1175922. DOI: 10.3389/fneur.2023.1175922
dc.identifier.doi http://dx.doi.org/10.3389/fneur.2023.1175922
dc.identifier.issn 1664-2295
dc.identifier.uri http://hdl.handle.net/10230/60122
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Neurol. 2023 Aug 2;14:1175922
dc.rights © 2023 Tate, Suárez-Calvet, Ekelund, Eriksson, Eriksdotter, Van Der Flier, Georges, Kivipelto, Kramberger, Lindgren, López, Lötjönen, Persson, Pla, Solomon, Thurfjell, Wimo, Winblad and Jönsson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Alzheimer’s disease
dc.subject.keyword Biomarkers
dc.subject.keyword Clinical decision support
dc.subject.keyword Dementia
dc.subject.keyword Precision medicine
dc.title Precision medicine in neurodegeneration: the IHI-PROMINENT project
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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