Laboratory and free-living gait performance in adults with COPD and healthy controls

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  • dc.contributor.author Buekers, Joren
  • dc.contributor.author Koch, Sarah
  • dc.contributor.author García Aymerich, Judith
  • dc.date.accessioned 2024-01-15T06:43:50Z
  • dc.date.available 2024-01-15T06:43:50Z
  • dc.date.issued 2023
  • dc.description.abstract Background: Gait characteristics are important risk factors for falls, hospitalisations and mortality in older adults, but the impact of COPD on gait performance remains unclear. We aimed to identify differences in gait characteristics between adults with COPD and healthy age-matched controls during 1) laboratory tests that included complex movements and obstacles, 2) simulated daily-life activities (supervised) and 3) free-living daily-life activities (unsupervised). Methods: This case-control study used a multi-sensor wearable system (INDIP) to obtain seven gait characteristics for each walking bout performed by adults with mild-to-severe COPD (n=17; forced expiratory volume in 1 s 57±19% predicted) and controls (n=20) during laboratory tests, and during simulated and free-living daily-life activities. Gait characteristics were compared between adults with COPD and healthy controls for all walking bouts combined, and for shorter (≤30 s) and longer (>30 s) walking bouts separately. Results: Slower walking speed (-11 cm·s-1, 95% CI: -20 to -3) and lower cadence (-6.6 steps·min-1, 95% CI: -12.3 to -0.9) were recorded in adults with COPD compared to healthy controls during longer (>30 s) free-living walking bouts, but not during shorter (≤30 s) walking bouts in either laboratory or free-living settings. Double support duration and gait variability measures were generally comparable between the two groups. Conclusion: Gait impairment of adults with mild-to-severe COPD mainly manifests during relatively long walking bouts (>30 s) in free-living conditions. Future research should determine the underlying mechanism(s) of this impairment to facilitate the development of interventions that can improve free-living gait performance in adults with COPD.
  • dc.description.sponsorship Support statement: This work was supported by the Mobilise-D project that has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement number 820820. This JU receives support from the European Union's Horizon 2020 research and innovation programme, and the European Federation of Pharmaceutical Industries and Associations (EFPIA). S. Del Din and L. Rochester were also supported by the Innovative Medicines Initiative 2 (IMI2) JU project IDEA-FAST – grant agreement 853981. S. Del Din, L. Alcock and L. Rochester were also supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre (BRC) based at The Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle University and the Cumbria, Northumberland and Tyne and Wear NHS Foundation Trust, and by the NIHR/Welcome Trust Clinical Research Facility infrastructure at Newcastle upon Tyne Hospitals NHS Foundation Trust. C. Mazzà and E. Buckley were also supported by the Sheffield BRC based at the Sheffield Teaching Hospital and the University of Sheffield. H. Demeyer is a post-doctoral research fellow of the Flemish Research Foundation (FWO Flanders). The Barcelona Institute for Global Health (ISGlobal) receives support from the Spanish Ministry of Science, Innovation and Universities through the “Centro de Excelencia Severo Ochoa 2019–2023” Programme (CEX 2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, the Department of Health, the IMI, the European Union, the EFPIA or any Associated Partners. Funding information for this article has been deposited with the Crossref Funder Registry.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Buekers J, Megaritis D, Koch S, Alcock L, Ammour N, Becker C, et al. Laboratory and free-living gait performance in adults with COPD and healthy controls. ERJ Open Res. 2023 Sep 25;9(5):00159-2023. DOI: 10.1183/23120541.00159-2023
  • dc.identifier.doi http://dx.doi.org/10.1183/23120541.00159-2023
  • dc.identifier.issn 2312-0541
  • dc.identifier.uri http://hdl.handle.net/10230/58676
  • dc.language.iso eng
  • dc.publisher European Respiratory Society
  • dc.relation.ispartof ERJ Open Res. 2023 Sep 25;9(5):00159-2023
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/820820
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/853981
  • dc.rights Copyright © The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. (http://creativecommons.org/licenses/by-nc/4.0/) For commercial reproduction rights and permissions contact permissions@ersnet.org
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.other Pulmons--Malalties obstructives
  • dc.title Laboratory and free-living gait performance in adults with COPD and healthy controls
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
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