Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies

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• dc.contributor.author van Veldhoven, Karin
• dc.contributor.author Kiss, Agneta
• dc.contributor.author Keski-Rahkonen, Pekka
• dc.contributor.author Robinot, Nivonirina
• dc.contributor.author Scalbert, Augustin
• dc.contributor.author Cullinan, Paul
• dc.contributor.author Chung, Kian Fan
• dc.contributor.author Collins, Peter
• dc.contributor.author Sinharay, Rudy
• dc.contributor.author Barratt, Benjamin M.
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Ambros, Albert
• dc.contributor.author Carrasco Turigas, Glòria
• dc.contributor.author Vlaanderen, Jelle
• dc.contributor.author Vermeulen, Roel
• dc.contributor.author Portengen, Lützen
• dc.contributor.author Kyrtopoulos, Sosterios A.
• dc.contributor.author Ponzi, Erica
• dc.contributor.author Chadeau-Hyam, Marc
• dc.contributor.author Vineis, Paolo
• dc.date.accessioned 2020-02-24T08:06:27Z
• dc.date.available 2020-02-24T08:06:27Z
• dc.date.issued 2019
• dc.description.abstract Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Levels of five and four pollutants were measured, respectively, using personal exposure monitoring devices. Serum samples were used for metabolomic profiling. The association between TRAP and levels of each metabolic feature was assessed. All pollutant levels were significantly higher at the high pollution sites. 29 and 77 metabolic features were associated with at least one pollutant in the Oxford Street II and TAPAS II studies, respectively, which related to 17 and 30 metabolic compounds. Little overlap was observed across pollutants for metabolic features, suggesting that different pollutants may affect levels of different metabolic features. After observing the annotated compounds, the main pathway suggested in Oxford Street II in association with NO2 was the acyl-carnitine pathway, previously found to be associated with cardio-respiratory disease. No overlap was found between the metabolic features identified in the two studies.
• dc.description.sponsorship This work was supported by the grant FP7 of the European Commission ‘Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe’ (EXPOsOMICS grant 308610 to PV). The Centre for Environment and Health is supported by the Medical Research Council and Public Health England (MR/L01341X/1). Erica Ponzi is funded by a Doc.Mobility grant from the Swiss National Science Foundation (SNSF grant P1ZHP2_178207).
• dc.format.mimetype application/pdf
• dc.identifier.citation van Veldhoven K, Kiss A, Keski-Rahkonen P, Robinot N, Scalbert A, Cullinan P, Chung KF, Collins P, Sinharay R, Barratt BM, Nieuwenhuijsen M, Rodoreda AA, Carrasco-Turigas G, Vlaanderen J, Vermeulen R, Portengen L, Kyrtopoulos SA, Ponzi E, Chadeau-Hyam M, Vineis P. Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies. Environ Int. 2019; 123:124-31. DOI: 10.1016/j.envint.2018.11.034
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2018.11.034
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/43690
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2019; 123:124-31
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308610
• dc.rights © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/BY/4.0/
• dc.subject.keyword Metabolomics
• dc.subject.keyword Randomized crossover trials
• dc.subject.keyword Traffic related air pollution
• dc.title Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion