Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

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• dc.contributor.author Choudhary, Priyanka
• dc.contributor.author Cosín Tomàs, Marta
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Kogevinas, Manolis
• dc.contributor.author Fossati, Serena
• dc.contributor.author Sebert, Sylvain
• dc.date.accessioned 2024-06-18T06:36:22Z
• dc.date.available 2024-06-18T06:36:22Z
• dc.date.issued 2024
• dc.description.abstract Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.
• dc.description.sponsorship This work received support from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733206 (LifeCycle), grant agreement no. 873749 (LongITools), and grant agreement no. 848158 (EarlyCause). The funding organisations were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The Supplementary File contains detail of the cohort specific acknowledgements and fundings.
• dc.format.mimetype application/pdf
• dc.identifier.citation Choudhary P, Monasso GS, Karhunen V, Ronkainen J, Mancano G, Howe CG, et al. Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence. Mol Psychiatry. 2024 Feb;29(2):348-58. DOI: 10.1038/s41380-023-02331-5
• dc.identifier.doi http://dx.doi.org/10.1038/s41380-023-02331-5
• dc.identifier.issn 1359-4184
• dc.identifier.uri http://hdl.handle.net/10230/60496
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Mol Psychiatry. 2024 Feb;29(2):348-58
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874739
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848158
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Genetics
• dc.subject.keyword Predictive markers
• dc.title Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion