Milk and dairy products intake is related to cognitive impairment at baseline in predimed plus trial

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  • dc.contributor.author Muñoz-Garach, Araceli
  • dc.contributor.author Castañer, Olga
  • dc.contributor.author Soria, María
  • dc.contributor.author Zomeño Fajardo, Maria Dolores
  • dc.contributor.author Schröder, Helmut, 1958-
  • dc.contributor.author Predimed-Plus Investigators
  • dc.date.accessioned 2022-02-24T08:43:57Z
  • dc.date.available 2022-02-24T08:43:57Z
  • dc.date.issued 2021
  • dc.description.abstract Scope: To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk. Methods and results: Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE). A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 ± 12.21 g, while patients with better MMSE score (27-30) consumed a mean of 341.23 ± 2.73 g (p < 0.05). Those subjects with the lower milk consumption (<220 g/day) had a higher MMSE score (28.35 ± 0.045). Higher intake of fermented dairy products was observed in participants with a lower MMSE score (OR 1.340, p = 0.003). A positive correlation was found between the consumption of whole milk and the MMSE score (r = 0.066, p < 0.001). Conclusions: These findings suggest that greater consumption of milk and dairy products could be associated with greater cognitive decline according to MMSE. Conversely, consumption of whole-fat milk could be linked with less cognitive impairment in the cross-sectional study.
  • dc.description.sponsorship This work was supported in part by grants from Instituto de Salud Carlos III (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926); the Cohorte PREDIMED-PLUS grant; the European Research Council (Advanced Research Grant 2013–2018, 340918); the Recercaixa grant (2013ACUP00194); grants from Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, PI0092/2017, PI0096/2017 and PI0137/2018); a grant from the Generalitat Valenciana (PROMETEO/2017/017); a SEMERGEN grant, and funds from the European Regional Development Fund (CB06/03). . This study has been co-funded by FEDER funds. A.M-G. is the recipient of a postdoctoral grant (Juan Rodes JR 17/00023) from the Spanish Ministry of Economy and Competitiveness. I.C-P. was supported by Rio Hortega (CM17/00169) and now is the recipient of a postdoctoral grant (Juan Rodes JR19/00054) from the Spanish Ministry of Economy and Competitiveness. JC.F-G was supported by a research contract from the Servicio Andaluz de Salud (SAS) (B-0003-2017). I.P.G. has received a grant from the Spanish Ministry of Education, Culture and Sports (FPU 17/01925). M.R.B-L was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER. We acknowledge M. Repice for English language editing of this article. All sources of funding of the study should be disclosed.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Muñoz-Garach A, Cornejo-Pareja I, Martínez-González MÁ, Bulló M, Corella D, Castañer O, et al. Milk and dairy products intake is related to cognitive impairment at baseline in predimed plus trial. Mol Nutr Food Res. 2021 Apr; 65(7): e2000728. DOI: 10.1002/mnfr.202000728
  • dc.identifier.doi http://dx.doi.org/10.1002/mnfr.202000728
  • dc.identifier.issn 1613-4125
  • dc.identifier.uri http://hdl.handle.net/10230/52561
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
  • dc.rights This is the peer reviewed version of the following article: Muñoz-Garach A, Cornejo-Pareja I, Martínez-González MÁ, Bulló M, Corella D, Castañer O, et al. Milk and dairy products intake is related to cognitive impairment at baseline in predimed plus trial. Mol Nutr Food Res. 2021 Apr; 65(7): e2000728, which has been published in final form at http://dx.doi.org/10.1002/mnfr.202000728. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Cognition
  • dc.subject.keyword Cognitive decline
  • dc.subject.keyword Consumption
  • dc.subject.keyword Dairy products
  • dc.subject.keyword Milk
  • dc.title Milk and dairy products intake is related to cognitive impairment at baseline in predimed plus trial
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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