Allergic contact dermatitis caused by nail acrylates in Europe. An EECDRG study
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- dc.contributor.author Gonçalo, Margarida
- dc.contributor.author Pinho, André
- dc.contributor.author Agner, Tove
- dc.contributor.author Andersen, Klaus E.
- dc.contributor.author Bruze, Magnus
- dc.contributor.author Diepgen, Thomas
- dc.contributor.author Foti, Caterina
- dc.contributor.author Giménez Arnau, Anna Maria
- dc.contributor.author Goossens, An
- dc.contributor.author Johanssen, Jeanne Duus
- dc.contributor.author Paulsen, Evy
- dc.contributor.author Svedman, Cecilia
- dc.contributor.author Wilkinson, Mark
- dc.contributor.author Aalto-Korte, Kristiina
- dc.date.accessioned 2018-10-31T08:35:44Z
- dc.date.issued 2018
- dc.description.abstract BACKGROUND: Allergic contact dermatitis (ACD) caused by nail acrylates, also including methacrylates and cyanoacrylates here, is being increasingly reported. METHODS: A retrospective study in 11 European Environmental Contact Dermatitis Research Group (EECDRG) clinics collected information on cases of ACD caused by nail acrylates diagnosed by aimed testing between 2013 and 2015. RESULTS: Among 18 228 studied patients, 136 had ACD caused by nail acrylates (0.75%; 95%CI: 0.60-0.90), representing 67.3% (95%CI: 60.4-73.7) of ACD cases caused by acrylates. There were 135 females and 1 male, with a mean age ± standard deviation of 36.7 ± 12.2 years; 59 (43.4%) were exposed as consumers, and 77 (56.6%) were occupationally exposed. Occupational cases were more frequent in southern Europe (83.7%), and were younger (mean age of 33.4 ± 8.9 years); most developed ACD during the first year at work (65.0%), and at least 11.7% had to leave their jobs. Skin lesions involved the hands in 121 patients (88.9%) and the face in 50 (36.8%), with the face being the only affected site in 14 (10.3%). Most patients reacted to two or more acrylates on patch testing, mainly to 2-hydroxyethyl methacrylate (HEMA) (92.5%), 2-hydroxypropyl methacrylate (88.6%), ethylene glycol dimethacrylate (69.2%), and ethyl cyanoacrylate (9.9%). CONCLUSIONS: Nail cosmetics were responsible for the majority of ACD cases caused by acrylates, affecting nail beauticians and consumers, and therefore calling for stricter regulation and preventive measures. As HEMA detects most cases, and isolated facial lesions may be overlooked, inclusion of this allergen in the baseline series may be warranted.
- dc.format.mimetype application/pdf
- dc.identifier.citation Gonçalo M, Pinho A, Agner T, Andersen KE, Bruze M, Diepgen T. et al. Allergic contact dermatitis caused by nail acrylates in Europe. An EECDRG study. Contact Dermatitis. 2018 Apr;78(4):254-260. DOI: 10.1111/cod.12942
- dc.identifier.doi http://dx.doi.org/10.1111/cod.12942
- dc.identifier.issn 0105-1873
- dc.identifier.uri http://hdl.handle.net/10230/35678
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Contact Dermatitis. 2018 Apr;78(4):254-60
- dc.rights This is the peer reviewed version of the following article: Gonçalo M, Pinho A, Agner T, Andersen KE, Bruze M, Diepgen T. et al. Allergic contact dermatitis caused by nail acrylates in Europe. An EECDRG study. Contact Dermatitis. 2018 Apr;78(4):254-260, which has been published in final form at http://dx.doi.org/10.1111/cod.12942. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Acrylates
- dc.subject.keyword Allergic contact dermatitis
- dc.subject.keyword Cosmetics
- dc.subject.keyword Hydroxyethyl methacrylate
- dc.subject.keyword Nail aesthetics
- dc.subject.keyword Occupational
- dc.subject.other Dermatitis de contacte
- dc.subject.other Al·lèrgia
- dc.title Allergic contact dermatitis caused by nail acrylates in Europe. An EECDRG study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion