Estimated phytate intake is associated with bone mineral density in mediterranean postmenopausal women

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• dc.contributor.author Sanchís, Pilar
• dc.contributor.author Prieto, Rafael M.
• dc.contributor.author Konieczna, Jadwiga
• dc.contributor.author Grases, Félix
• dc.contributor.author Abete, Itziar
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Martín, Vicente
• dc.contributor.author Ruiz-Canela, Miguel
• dc.contributor.author Babio, Nancy
• dc.contributor.author García-Gavilán, Jesús Francisco
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author Costa-Bauza, Antonia
• dc.contributor.author Martínez, José Alfredo
• dc.contributor.author Romaguera Bosch, Dora
• dc.date.accessioned 2024-04-09T06:27:05Z
• dc.date.available 2024-04-09T06:27:05Z
• dc.date.issued 2023
• dc.description.abstract The main objective of this work was to explore the association of dietary phytate intake with bone mineral density (BMD) in a Mediterranean population of postmenopausal women. For this purpose, a cross-sectional analysis of 561 women aged 55-75 years with overweight/obesity and metabolic syndrome from a Mediterranean area and with data on dual-energy X-ray absorptiometry (DXA) scans in femur and lumbar spine was performed. Estimated phytate intake was calculated using a validated food frequency questionnaire. Our results indicated that phytate intake was associated with BMD [β(95%CI) per each 25 mg/100 kcal] in femoral neck [0.023(0.060-0.040) g/cm2], femoral Ward's triangle [0.033(0.013-0.054) g/cm2], total femur [0.018(0.001-0.035) g/cm2], and all the analyzed lumbar spine sites [L1-L4: 0.033(0.007-0.059) g/cm2] after adjusting for potential confounders. The sensitivity analysis showed that phytate intake was directly associated with lumbar spine BMD in women younger than 66 years, with a body mass index higher than 32.6 kg/cm2 and without type 2 diabetes (all p-for interactions < 0.05). The overall results indicated that phytate, a substance present in food as cereals, legumes and nuts, was positively associated with BMD in Mediterranean postmenopausal women. Phytate may have a protective effect on bone resorption by adsorbing on the surfaces of HAP. Nevertheless, large, long-term, and randomized prospective clinical studies must be performed to assess the possible benefits of phytate consumption on BMD in postmenopausal women.
• dc.description.sponsorship This research was funded by the ‘National Institutes of Health’ [NIH 1R01DK127601] granted to MR-C and JS-S; ‘European Research Council’ [Advanced Research Grant 2014–2019; agreement #340918] granted to MÁM-G; and the ‘Spanish National Health Institute of Health Carlos III (ISCIII)’, through ‘CIBEROBN’ and ‘Fondo de Investigación para la Salud’ (FIS), which is co-funded by the ‘European Regional Development Fund’ [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462,PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722,PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919,PI14/00853,PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662,PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366,PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508,PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032,PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158, PI20/0471]; the ‘Especial Action Project’ entitled: Implementación y evaluación de una intervención intensive sobre la actividad física Cohorte PREDIMEDPlus grant to JS-S; the ‘Recercaixa’ [number 2013ACUP00194] grant to JS-S; grants from the ‘Consejería de Salud de la Junta de Andalucía’ (PI0458/2013, PS0358/2016,PI0137/2018); the [PROMETEO/2017/017] grant from the ‘Generalitat Valenciana’; the SEMERGEN grant. Juan de la Cierva-Incorporación research grant [IJC2019-042420-I] of the ‘Spanish Ministry of Economy, Industry and Competitiveness’ and ‘European Social Funds’ to JK. This work was also partially supported by ‘ICREA’ under the ICREA Academia programme. None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sanchis P, Prieto RM, Konieczna J, Grases F, Abete I, Salas-Salvadó J, et al. Estimated phytate intake is associated with bone mineral density in mediterranean postmenopausal women. Nutrients. 2023 Apr 6;15(7):1791. DOI: 10.3390/nu15071791
• dc.identifier.doi http://dx.doi.org/10.3390/nu15071791
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/59691
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Nutrients. 2023 Apr 6;15(7):1791
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/IJC2019-042420-I
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword DXA
• dc.subject.keyword Bone mineral density
• dc.subject.keyword Phytate
• dc.subject.keyword Postmenopausal women
• dc.title Estimated phytate intake is associated with bone mineral density in mediterranean postmenopausal women
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion