Budget impact of ferric carboxymaltose treatment in patients with chronic heart failure and iron deficiency in Spain
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- dc.contributor.author Delgado, Juan F.
- dc.contributor.author Oliva, Juan
- dc.contributor.author González-Franco, Álvaro
- dc.contributor.author Cepeda, Jose María
- dc.contributor.author García-García, Jose Ángel
- dc.contributor.author González-Domínguez, Almudena
- dc.contributor.author García-Casanovas, Albert
- dc.contributor.author Jiménez Merino, Silvia
- dc.contributor.author Comín Colet, Josep
- dc.date.accessioned 2021-11-04T07:38:27Z
- dc.date.available 2021-11-04T07:38:27Z
- dc.date.issued 2020
- dc.description.abstract Objective: The treatment of iron deficiency (ID) with ferric carboxymaltose (FCM) improves the functional class and quality of life of chronic heart failure (CHF) patients with reduced left ventricular ejection fraction (LVEF), and reduces the rate of hospitalization due to worsening CHF. This study aims to evaluate the budget impact for the Spanish National Health System (SNHS) of treating ID in reduced LVEF CHF with FCM compared to non-iron treatment. Methods: We simulated a hypothetical cohort of 1000 CHF patients with ID and reduced LVEF based on the Spanish population characteristics. A decision-analytic model was also built using the data from the largest FCM clinical trial (CONFIRM-HF) that lasted for a year. We considered the use of healthcare resources from a national prospective study. A deterministic sensitivity analysis was carried out varying the corresponding baseline data by ±25%. Results: The cost of treating the simulated population with FCM was €2,570,914, while that of the non-iron treatment was €3,105,711, which corresponds to a cost saving of €534,797 per 1,000 patients in one year. Cost savings were mainly due to a decrease in the number of hospitalizations. All sensitivity analysis showed cost savings for the SNHS. Conclusions: FCM results in an annual cost saving of €534.80 per patient, and would thus be expected to reduce the economic burden of CHF in Spain.
- dc.format.mimetype application/pdf
- dc.identifier.citation Delgado JF, Oliva J, González-Franco Á, Cepeda JM, García-García JÁ, González-Domínguez A, et al. Budget impact of ferric carboxymaltose treatment in patients with chronic heart failure and iron deficiency in Spain. J Med Econ. 2020 Dec; 23(12):1418-24. DOI: 10.1080/13696998.2020
- dc.identifier.doi http://dx.doi.org/10.1080/13696998.2020
- dc.identifier.issn 1369-6998
- dc.identifier.uri http://hdl.handle.net/10230/48900
- dc.language.iso eng
- dc.publisher Taylor & Francis
- dc.rights © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Budget impact
- dc.subject.keyword H51
- dc.subject.keyword I13
- dc.subject.keyword Chronic heart failure
- dc.subject.keyword Ferric carboxymaltose
- dc.subject.keyword Heart failure
- dc.subject.keyword Iron deficiency
- dc.title Budget impact of ferric carboxymaltose treatment in patients with chronic heart failure and iron deficiency in Spain
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion