Differences in mortality in a cohort of cocaine use disorder patients with concurrent alcohol or opiates disorder

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  • dc.contributor.author Colell Ortega, Esther, 1961-ca
  • dc.contributor.author Domingo-Salvany, Antòniaca
  • dc.contributor.author Espelt Hernández, Albert, 1981-ca
  • dc.contributor.author Parés Badell, O.ca
  • dc.contributor.author Brugal i Puig, M. Teresaca
  • dc.date.accessioned 2018-09-28T07:52:12Z
  • dc.date.issued 2018
  • dc.description.abstract AIMS: To study mortality in a cohort of cocaine use disorder patients, and compare results in those with concurrent alcohol or opiates disorder. DESIGN, SETTING AND PARTICIPANTS: A cohort of 10 539 cocaine use disorder individuals entering drug treatment in public out-patient centres in the city of Barcelona was followed from 1997 to 2011. Participants were divided at baseline into three groups: those with only cocaine use disorder (CUD), those with cocaine and alcohol use disorder but not opioid (CAUD) and those with cocaine and opioid use disorder (COUD). Mortality was assessed through the Spanish National Mortality Register. MEASUREMENTS: Crude mortality rates (CMR), standardized mortality ratios (SMR) and rate ratios (RR) were calculated for each group. A multivariable Cox regression model was fitted to obtain adjusted mortality hazard ratios (aHR) of CAUD and COUD with respect to CUD. Specific mortality causes were also examined. FINDINGS: The total of 716 deaths registered resulted in a CMR = 6.0/1000 person-years (PY); 95% confidence interval (CI) = 5.1-7.0 for CUD, CMR = 5.8/1000 PY (95% CI = 4.9-6.7) for CAUD and CMR = 20.7/1000 PY (95% CI = 18.8-22.8) for COUD, with no significant differences among sexes. Compared with the general population, mortality was four times higher (SMR = 4.1, 95% CI = 3.5-4.8) among CUD, more than three times among CAUD (SMR = 3.4, 95% CI = 2.9-3.9) and more than 10 times among COUD (SMR = 11.6, 95% CI = 10.5-12.8), being always higher in women. External injuries, led by overdose, accumulated the biggest percentage of deaths among the three groups, but infectious diseases showed the highest excess mortality. Some differences regarding causes of death were observed between the three groups. CONCLUSIONS: Mortality risk and excess mortality are significantly greater among those with cocaine and opiates use disorder than among people with only cocaine use disorder or cocaine and alcohol use disorder.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Colell E, Domingo-Salvany A, Espelt A, Parés-Badell O, Brugal MT. Differences in mortality in a cohort of cocaine use disorder patients with concurrent alcohol or opiates disorder. Addiction. 2018 Jun;113(6):1045-1055. DOI: 10.1111/add.14165
  • dc.identifier.doi http://dx.doi.org/10.1111/add.14165
  • dc.identifier.issn 0965-2140
  • dc.identifier.uri http://hdl.handle.net/10230/35535
  • dc.language.iso eng
  • dc.publisher Wileyca
  • dc.relation.ispartof Addiction. 2018 Jun;113(6):1045-55
  • dc.rights This is the peer reviewed version of the following article:Colell E, Domingo-Salvany A, Espelt A, Parés-Badell O, Brugal MT. Differences in mortality in a cohort of cocaine use disorder patients with concurrent alcohol or opiates disorder. Addiction. 2018 Jun;113(6):1045-1055, which has been published in final form at http://dx.doi.org/10.1111/add.14165. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Alcohol use disorder
  • dc.subject.keyword Spain
  • dc.subject.keyword Cause of death
  • dc.subject.keyword Cocaine use disorder
  • dc.subject.keyword Excess mortality
  • dc.subject.keyword Longitudinal study
  • dc.subject.keyword Mortality rate
  • dc.subject.keyword Opioid use disorder
  • dc.subject.other Mortalitat -- Espanya
  • dc.subject.other Cocaïna
  • dc.subject.other Alcohol -- Toxicologia
  • dc.title Differences in mortality in a cohort of cocaine use disorder patients with concurrent alcohol or opiates disorderca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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