Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
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- dc.contributor.author Brune-Ingebretsen, Synne
- dc.contributor.author Høgestøl, Einar A.
- dc.contributor.author de Rosbo, Nicole Kerlero
- dc.contributor.author Berg-Hansen, Pål
- dc.contributor.author Brunborg, Cathrine
- dc.contributor.author Blennow, Kaj
- dc.contributor.author Zetterberg, Henrik
- dc.contributor.author Paul, Friedemann
- dc.contributor.author Uccelli, Antonio
- dc.contributor.author Villoslada, Pablo
- dc.contributor.author Harbo, Hanne F.
- dc.contributor.author Berge, Tone
- dc.date.accessioned 2025-04-29T09:44:34Z
- dc.date.available 2025-04-29T09:44:34Z
- dc.date.issued 2023
- dc.description.abstract Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.en
- dc.description.sponsorship This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320).en
- dc.format.mimetype application/pdf
- dc.identifier.citation Brune-Ingebretsen S, Høgestøl EA, de Rosbo NK, Berg-Hansen P, Brunborg C, Blennow K, et al. Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis. J Neuroimmunol. 2023 Sep;382:578175. DOI: 10.1016/j.jneuroim.2023.578175
- dc.identifier.doi http://dx.doi.org/10.1016/j.jneuroim.2023.578175
- dc.identifier.issn 0165-5728
- dc.identifier.uri http://hdl.handle.net/10230/70235
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Journal of Neuroimmunology. 2023 Sep;382:578175
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101053962
- dc.rights © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Multiple sclerosisen
- dc.subject.keyword Serum neurofilament light chainen
- dc.subject.keyword Immune cell subset frequenciesen
- dc.subject.keyword Biomarkersen
- dc.subject.keyword Disease worseningen
- dc.title Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosisen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion