BIPS: BIANA Interolog Prediction Server. A tool for protein-protein interaction inference

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• dc.contributor.author García-García, Javier, 1982-ca
• dc.contributor.author Schleker, Sylviaca
• dc.contributor.author Klein-Seetharaman, Judithca
• dc.contributor.author Oliva Miguel, Baldomeroca
• dc.date.accessioned 2015-03-17T08:23:53Z
• dc.date.available 2015-03-17T08:23:53Z
• dc.date.issued 2012ca
• dc.description.abstract Protein-protein interactions (PPIs) play a crucial role in biology, and high-throughput experiments have greatly increased the coverage of known interactions. Still, identification of complete inter- and intraspecies interactomes is far from being complete. Experimental data can be complemented by the prediction of PPIs within an organism or between two organisms based on the known interactions of the orthologous genes of other organisms (interologs). Here, we present the BIANA (Biologic Interactions and Network Analysis) Interolog Prediction Server (BIPS), which offers a web-based interface to facilitate PPI predictions based on interolog information. BIPS benefits from the capabilities of the framework BIANA to integrate the several PPI-related databases. Additional metadata can be used to improve the reliability of the predicted interactions. Sensitivity and specificity of the server have been calculated using known PPIs from different interactomes using a leave-one-out approach. The specificity is between 72 and 98%, whereas sensitivity varies between 1 and 59%, depending on the sequence identity cut-off used to calculate similarities between sequences. BIPS is freely accessible at http://sbi.imim.es/BIPS.php.
• dc.description.sponsorship This work was funded by the Spanish Ministry of Science and Innovation (MICINN); partners of the ERASysBio+ initiative supported under the EU ERA-NET Plus scheme in FP7 (SHIPREC) Euroinvestigación [EUI2009-04018], as well as FEDER [BIO2011-22568, PSE-0100000-2009]
• dc.format.mimetype application/pdfca
• dc.identifier.citation Garcia-Garcia J, Schleker S, Klein-Seetharaman J, Oliva B. BIPS: BIANA/nInterolog Prediction Server. A tool for protein-protein interaction inference. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W147-51. doi:/n10.1093/nar/gks553ca
• dc.identifier.doi http://dx.doi.org/10.1093/nar/gks553
• dc.identifier.issn 0305-1048ca
• dc.identifier.uri http://hdl.handle.net/10230/23202
• dc.language.iso engca
• dc.publisher Oxford University Pressca
• dc.relation.ispartof Nucleic Acids Research. 2012 Jul;40(Web Server issue):W147-51
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/EUI2009-04018
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-22568
• dc.rights © 2010 Javier Garcia-Garcia et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly citedca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0
• dc.subject.other Proteïnes
• dc.title BIPS: BIANA Interolog Prediction Server. A tool for protein-protein interaction inferenceca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca