Abuse potential of cathinones in humans: a systematic review
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- dc.contributor.author Poyatos, Lourdes
- dc.contributor.author Torres, Adrián
- dc.contributor.author Papaseit Fontanet, Esther
- dc.contributor.author Pérez Mañá, Clara
- dc.contributor.author Hladun, Olga
- dc.contributor.author Núñez-Montero, Melani
- dc.contributor.author de la Rosa, Georgina
- dc.contributor.author Torrens, Marta
- dc.contributor.author Fuster, Daniel
- dc.contributor.author Muga, Roberto
- dc.contributor.author Farré Albaladejo, Magí
- dc.date.accessioned 2022-11-14T07:57:38Z
- dc.date.available 2022-11-14T07:57:38Z
- dc.date.issued 2022
- dc.description.abstract Introduction and objective: assessing the abuse potential of new substances with central nervous system activity is essential for preventing possible risks of misuse and addiction. The same methodology is recommended for the evaluation of the abuse potential of recreational drugs. This systematic review aims to assess the pharmacological effects related to the abuse potential and pharmacokinetics of cathinones, which are evaluated in both experimental and prospective observational studies in humans. Materials and Methods: A systematic search of the published literature was conducted to retrieve studies that had administered cathinone, mephedrone, methylone, and diethylpropion to evaluate their acute pharmacological effects related to abuse potential. Results: The search yielded 583 results, 18 of which were included to assess the abuse potential of cathinone (n = 5), mephedrone (n = 7), methylone (n = 1), and diethylpropion (n = 5). All four substances induce stimulant and euphorigenic effects that resemble those of amphetamines and MDMA, and their different intensities may be associated with varying levels of abuse potential. Conclusions: Cathinone, mephedrone, methylone, and diethylpropion induce a range of desirable and reinforcing effects that may, to some extent, result in abuse potential. Further investigation is needed to minimize and prevent their impact on society and public health.
- dc.format.mimetype application/pdf
- dc.identifier.citation Poyatos L, Torres A, Papaseit E, Pérez-Mañá C, Hladun O, Núñez-Montero M, et al. Abuse potential of cathinones in humans: a systematic review. J Clin Med. 2022 Feb 15; 11(4): 1004. DOI: 10.3390/jcm11041004
- dc.identifier.doi http://dx.doi.org/10.3390/jcm11041004
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/54834
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2022. Poyatos L, Torres A, Papaseit E, Pérez-Mañá C, Hladun O, Núñez-Montero M, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Abuse potential
- dc.subject.keyword Cathinone
- dc.subject.keyword Diethylpropion
- dc.subject.keyword Mephedrone (4-methylmethcathinone)
- dc.subject.keyword Methylone (3,4-methylenedioxymethcathinone)
- dc.subject.keyword New psychoactive substance
- dc.subject.keyword Pharmacokinetics
- dc.subject.keyword Pharmacological effects
- dc.title Abuse potential of cathinones in humans: a systematic review
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion