Multi-omics signatures of the human early life exposome

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• dc.contributor.author Maitre, Léa
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author Hernández Ferrer, Carles
• dc.contributor.author Vives Usano, Marta, 1990-
• dc.contributor.author Ruiz-Arenas, Carlos
• dc.contributor.author Pelegrí-Sisó, Dolors
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Borràs, Eva
• dc.contributor.author Sabidó Aguadé, Eduard, 1981-
• dc.contributor.author Estivill, Xavier, 1955-
• dc.contributor.author González, Juan Ramón
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2023-01-10T06:45:22Z
• dc.date.available 2023-01-10T06:45:22Z
• dc.date.issued 2022
• dc.description.abstract Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations ( https://helixomics.isglobal.org/ ) will serve to guide future investigation into the biological imprints of the early life exposome.
• dc.description.sponsorship We would like to thank all the families for their generous contribution. The study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874583 (ATHLETE project). Data were collected as part of the European Community’s Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333 (HELIX project). BiB received core infrastructure funding from the Wellcome Trust (WT101597MA) and a joint grant from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. L.M. is funded by a Juan de la Cierva-Incorporación fellowship (IJC2018-035394-I) awarded by the Spanish Ministerio de Economía, Industria y Competitividad. M.V.-U. and C.R.-A. were supported by a FI fellowship from the Catalan Government (FI-DGR 2015 and #016FI_B 00272). M. Casas received funding from Instituto Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128).
• dc.format.mimetype application/pdf
• dc.identifier.citation Maitre L, Bustamante M, Hernández-Ferrer C, Thiel D, Lau CE, Siskos AP et al. Multi-omics signatures of the human early life exposome. Nat Commun. 2022 Nov 21;13(1):7024. DOI: 10.1038/s41467-022-34422-2
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-022-34422-2
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/55243
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Commun. 2022 Nov 21;13(1):7024
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Prognostic markers
• dc.subject.keyword Risk factors
• dc.subject.keyword Systems biology
• dc.title Multi-omics signatures of the human early life exposome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion