Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010

González Candela, Fernando; Astray, Jenaro; Alonso Caballero, Jordi; Castro, Ady; Cantón, Rafael; Galán, Juan Carlos; Garin Boronat, Olatz, 1979-; Sáez, Marc; Soldevila, Núria; Baricot, Maretva; Castilla, Jesús; Godoy i García, Pere; Delgado Rodríguez, Miguel; Martín, Vicente; Quintana, José María; Tamames, Sonia; Domínguez García, Àngela; CIBERESP Cases and Controls in Pandemic Influenza Working Group

Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010

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dc.contributor.author González Candela, Fernandoca
dc.contributor.author Astray, Jenaroca
dc.contributor.author Alonso Caballero, Jordica
dc.contributor.author Castro, Adyca
dc.contributor.author Cantón, Rafaelca
dc.contributor.author Galán, Juan Carlosca
dc.contributor.author Garin Boronat, Olatz, 1979-ca
dc.contributor.author Sáez, Marcca
dc.contributor.author Soldevila, Núriaca
dc.contributor.author Baricot, Maretvaca
dc.contributor.author Castilla, Jesúsca
dc.contributor.author Godoy i García, Pereca
dc.contributor.author Delgado Rodríguez, Miguelca
dc.contributor.author Martín, Vicenteca
dc.contributor.author Quintana, José Maríaca
dc.contributor.author Tamames, Soniaca
dc.contributor.author Domínguez García, Àngelaca
dc.contributor.author CIBERESP Cases and Controls in Pandemic Influenza Working Groupca
dc.date.accessioned 2015-05-08T07:19:15Z
dc.date.available 2015-05-08T07:19:15Z
dc.date.issued 2012ca
dc.description.abstract The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population.en
dc.description.sponsorship Funding was provided by project GR09/0030 of the Instituto de Salud Carlos III/Ministerio de Ciencia e Innovación, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripten
dc.format.mimetype application/pdfca
dc.identifier.citation González-Candelas F, Astray J, Alonso J, Castro A, Canton R, Galan JC et al. Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010. PLoS ONE. 2012;7(3):e33139. DOI: 10.1371/journal.pone.0033139ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0033139
dc.identifier.issn 1932-6203ca
dc.identifier.uri http://hdl.handle.net/10230/23536
dc.language.iso engca
dc.publisher Public Library of Science (PLoS)ca
dc.relation.ispartof PLoS ONE. 2012;7(3):e33139
dc.rights © 2012 González-Candelas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Grip A (H1N1)ca
dc.subject.other Epidemiologia -- Investigació -- Espanyaca
dc.title Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010en
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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