Marcadores estromales en el cáncer de pulmón: la influencia de la enfermedad pulmonar obstructiva crònica

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• dc.contributor.author Tang, Jun
• dc.contributor.author Ramis Cabrer, Daniel, 1993-
• dc.contributor.author Curull Serrano, Víctor
• dc.contributor.author Mateu Jiménez, Mercè, 1990-
• dc.contributor.author Almagro, Klara
• dc.contributor.author Duran, Xavier
• dc.contributor.author Pijuan Andujar, Lara
• dc.contributor.author Rodríguez-Fuster, Alberto
• dc.contributor.author Aguiló Espases, Rafael
• dc.contributor.author Barreiro Portela, Esther
• dc.date.accessioned 2021-05-21T07:05:18Z
• dc.date.issued 2021
• dc.description.abstract Background: Stroma, mainly composed by fibroblasts, extracellular matrix (ECM) and vessels, may play a role in tumorigenesis and cancer progression. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for LC. We hypothesized that markers of fibroblasts, ECM and endothelial cells may differ in tumors of LC patients with/without COPD. Methods: Markers of cultured cancer-associated fibroblasts and normal fibroblasts [CAFs and NFs, respectively, vimentin and alpha-smooth muscle actin (SMA) markers, immunofluorescence in cultured lung fibroblasts], ECM, and endothelial cells (type I collagen and CD31 markers, respectively, immunohistochemistry) were identified in lung tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 15 LC-COPD patients and 15 LC-only patients. Results: Numbers of CAFs significantly increased, while those of NFs significantly decreased in tumor samples compared to non-tumor specimens of both LC and LC-COPD patients. Endothelial cells (CD31) significantly decreased in tumor samples compared to non-tumor specimens only in LC patients. No significant differences were seen in levels of type I collagen in any samples or study groups. Conclusions: Vascular endothelial marker CD31 expression was reduced in tumors of non-COPD patients, while type I collagen levels did not differ between groups. A rise in CAFs levels was detected in lung tumors of patients irrespective of airway obstruction. Low levels of CD31 may have implications in the overall survival of LC patients, especially in those without underlying airway obstruction. Identification of CD31 role as a prognostic and therapeutic biomarker in lung tumors of patients with underlying respiratory diseases warrants attention.
• dc.format.mimetype application/pdf
• dc.identifier.citation Tang J, Ramis-Cabrer D, Curull V, Mateu-Jiménez M, Almagro K, Duran X, et al. Marcadores estromales en el cáncer de pulmón: la influencia de la enfermedad pulmonar obstructiva crònica. Arch Bronconeumol. 2021 Feb; 57(2): 130-7. DOI: 10.1016/j.arbres.2020.09.005
• dc.identifier.doi http://dx.doi.org/10.1016/j.arbres.2020.09.005
• dc.identifier.issn 0300-2896
• dc.identifier.uri http://hdl.handle.net/10230/47637
• dc.language.iso spa
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.arbres.2020.09.005
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword COPD
• dc.subject.keyword Cancer-associated fibroblasts
• dc.subject.keyword Cáncer de pulmón
• dc.subject.keyword EPOC
• dc.subject.keyword Endothelial cell marker CD31
• dc.subject.keyword Estroma
• dc.subject.keyword Extracellular matrix
• dc.subject.keyword Fibroblastos asociados al cáncer
• dc.subject.keyword Lung cancer
• dc.subject.keyword Marcador de células endoteliales CD31
• dc.subject.keyword Matriz extracelular
• dc.subject.keyword Stroma
• dc.title Marcadores estromales en el cáncer de pulmón: la influencia de la enfermedad pulmonar obstructiva crònica
• dc.title.alternative Markers of stroma in lung cancer: influence of COPD
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion