Effects of polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors after a long-term follow-up in the PREDIMED Study.

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  • dc.contributor.author Guo, Xiaohuica
  • dc.contributor.author Tresserra-Rimbau, Annaca
  • dc.contributor.author Estruch, Ramónca
  • dc.contributor.author Martínez-González, Miguel Ángel, 1957-ca
  • dc.contributor.author Medina-Remón, Alexanderca
  • dc.contributor.author Castañer, Olgaca
  • dc.contributor.author Corella, Doloresca
  • dc.contributor.author Salas-Salvadó, Jordica
  • dc.contributor.author Lamuela-Raventós, Rosa M.ca
  • dc.date.accessioned 2016-04-27T09:43:11Z
  • dc.date.available 2016-04-27T09:43:11Z
  • dc.date.issued 2016
  • dc.description.abstract Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639). We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (β = -8.563; P = 0.007), glucose concentration (β = -4.164; P = 0.036), and diastolic blood pressure (β = -1.316; P = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.ca
  • dc.description.sponsorship This study was supported by CICYT (AGL2013-49083- C3-1-R) from the Spanish Ministry of Economy and Competitiveness (MEC), the Generalitat de Catalunya (GC) 2014 SGR 773 and Instituto de Salud Carlos III, ISCIII (CIBEROBN). CIBEROBN is an initiative of ISCIII, Spain. Xiaohui Guo received support from China Scholarship Council (CSC). Alexander Medina-Remon thanks the ´“Juan de la Cierva” postdoctoral program (JCI-2012-13463) from MEC
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Guo X, Tresserra-Rimbau A, Estruch R, Martínez-González MA, Medina-Remón A, Castañer O. et al. Effects of polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors after a long-term follow-up in the PREDIMED Study. Oxid Med Cell Longev. 2016;2016:2572606. doi: 10.1155/2016/2572606ca
  • dc.identifier.doi http://dx.doi.org/10.1155/2016/2572606
  • dc.identifier.issn 1942-0994
  • dc.identifier.uri http://hdl.handle.net/10230/26179
  • dc.language.iso engca
  • dc.publisher Hindawi Publishing Corporationca
  • dc.relation.ispartof Oxidative Medicine and Cellular Longevity. 2016;2016:2572606
  • dc.rights Copyright © 2016 Xiaohui Guo et al. This is an open access article distributed under the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Polifenolsca
  • dc.subject.other Sistema cardiovascular -- Malaltiesca
  • dc.title Effects of polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors after a long-term follow-up in the PREDIMED Study.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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