Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexia
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- dc.contributor.author Coma Camprodón, Mireiaca
- dc.contributor.author Vicente García, Rubén, 1978-ca
- dc.contributor.author Busquets, Silviaca
- dc.contributor.author Carbó, Neusca
- dc.contributor.author Tamkun, Michael M.ca
- dc.contributor.author López Soriano, Francisco J.ca
- dc.contributor.author Argilés, Josep M.ca
- dc.contributor.author Felipe, Antonioca
- dc.date.accessioned 2016-01-20T19:28:12Z
- dc.date.available 2016-01-20T19:28:12Z
- dc.date.issued 2003
- dc.description.abstract Cancer-induced cachexia affects most advanced cancer patients. It is characterized by anorexia, profound metabolic dysfunctions, and severe neurological disorders. Here we show that voltage-gated potassium channel (Kv) expression is impaired in the brain of tumor-bearing animals. Expression of both delayed rectifier (Kv1.1, Kv1.2, Kv1.3, Kv1.5, Kv1.6, Kv2.1, Kv3.1, Kv4.2) and A-type potassium channels (Kv1.4, Kv3.3, Kv3.4) was greatly down-regulated in brain from animals bearing a Yoshida AH-130 ascites hepatoma. The possible compensatory mechanisms (Kv1.4/Kv4.2), expression of redundant genes (Kv3.1/Kv3.3) and heteromultimeric channel formation (Kv2.1/Kv9.3) were also affected. The high circulating levels of TNFalpha and the reduced expression of the anti-apoptotic protein Bcl-XL found in the brain of tumor-bearing animals indicate that this response could be mediated by an increase in brain cell death due to apoptosis. The results suggest that brain function is impaired during cancer cachexia, and may account for the cancer-induced anorectic response and other neurological alterations.ca
- dc.description.sponsorship This study was supported by grants from the Ministerio de Ciencia y Tecnología (BFI2002-00764 to A.F., BFI2002-02186 to J.M.A.) and Ministerio de Sanidad (FIS, 00/1116 to J.M.A.), Spain, and Universitat de Barcelona (to A.F.). R.V. holds a fellowship from the Universitat de Barcelona.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Coma M, Vicente R, Busquets S, Carbó N, Tamkun MM, López-Soriano FJ et al. Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexia. FEBS Letters. 2003;536(1-3):45-50. DOI: 10.1016/S0014-5793(03)00009-7ca
- dc.identifier.doi http://dx.doi.org/10.1016/S0014-5793(03)00009-7
- dc.identifier.issn 0014-5793
- dc.identifier.uri http://hdl.handle.net/10230/25611
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof FEBS Letters. 2003;536(1-3):45-50
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/BFI2002-00764
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/BFI2002-02186
- dc.rights © Elsevier. This is the published version of an article http://dx.doi.org/10.1016/S0014-5793(03)00009-7 that appeared in the journal FEBS Letters. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Potassium channel
- dc.subject.keyword Cancer cachexia
- dc.subject.keyword Apoptosis
- dc.subject.keyword Brain
- dc.subject.keyword Anorexia
- dc.subject.other Cervell -- Metabolismeca
- dc.subject.other Canals de potassica
- dc.title Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexiaca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca