Skin microbiome transplantation and manipulation: Current state of the art
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- dc.contributor.author Callewaert, Chris
- dc.contributor.author Knödlseder, Nastassia
- dc.contributor.author Karoglan, Ante
- dc.contributor.author Güell Cargol, Marc, 1982-
- dc.contributor.author Paetzold, Bernhard, 1981-
- dc.date.accessioned 2021-02-15T06:48:07Z
- dc.date.available 2021-02-15T06:48:07Z
- dc.date.issued 2021
- dc.description.abstract Many skin conditions are associated with an imbalance in the skin microbiome. In recent years, the skin microbiome has become a hot topic, for both therapeutic and cosmetic purposes. The possibility of manipulating the human skin microbiome to address skin conditions has opened exciting new paths for therapy. Here we review the skin microbiome manipulation strategies, ranging from skin microbiome transplantation, over skin bacteriotherapy to the use of prebiotics, probiotics and postbiotics. We summarize all efforts undertaken to exchange, manipulate, transplant or selectively apply the skin microbiome to date. Multiple microbial groups have been targeted, since they have been proven to be beneficial for skin health. We focus on the most common skin disorders and their associated skin microbiome dysbiosis and we review the existing scientific data and clinical trials undertaken to combat these skin conditions. The skin microbiome represents a novel platform for therapy. Transplantation of a complete microbiome or application of single strains has demonstrated beneficial therapeutic application.
- dc.format.mimetype application/pdf
- dc.identifier.citation Callewaert C, Knödlseder N, Karoglan A, Güell M, Paetzold B. Skin microbiome transplantation and manipulation: Current state of the art. Comput Struct Biotechnol J. 2021; 19:624-31. DOI: 10.1016/j.csbj.2021.01.001
- dc.identifier.doi http://dx.doi.org/10.1016/j.csbj.2021.01.001
- dc.identifier.issn 2001-0370
- dc.identifier.uri http://hdl.handle.net/10230/46470
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Comput Struct Biotechnol J. 2021; 19:624-31
- dc.rights © 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Microbiome manipulation
- dc.subject.keyword Microbiome transplantation
- dc.subject.keyword Skin microbiome
- dc.subject.keyword Skin microbiome modulation
- dc.title Skin microbiome transplantation and manipulation: Current state of the art
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion