Neurodevelopmental correlates of the emerging adult self
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- dc.contributor.author Davey, Christopher G.
- dc.contributor.author Fornito, Alex
- dc.contributor.author Pujol Nuez, Jesús
- dc.contributor.author Breakspear, Michael
- dc.contributor.author Schmaal, Lianne
- dc.contributor.author Harrison, Ben J.
- dc.date.accessioned 2019-12-03T07:56:28Z
- dc.date.available 2019-12-03T07:56:28Z
- dc.date.issued 2019
- dc.description.abstract The self-concept - the set of beliefs that a person has about themselves - shows significant development from adolescence to early adulthood, in parallel with brain development over the same period. We sought to investigate how age-related changes in self-appraisal processes corresponded with brain network segregation and integration in healthy adolescents and young adults. We scanned 88 participants (46 female), aged from 15 to 25 years, as they performed a self-appraisal task. We first examined their patterns of activation to self-appraisal, and replicated prior reports of reduced dorsomedial prefrontal cortex activation with older age, with similar reductions in precuneus, right anterior insula/operculum, and a region extending from thalamus to striatum. We used independent component analysis to identify distinct anterior and posterior components of the default mode network (DMN), which were associated with the self-appraisal and rest-fixation parts of the task, respectively. Increasing age was associated with reduced functional connectivity between the two components. Finally, analyses of task-evoked interactions between pairs of nodes within the DMN identified a subnetwork that demonstrated reduced connectivity with increasing age. Decreased network integration within the DMN appears to be an important higher-order maturational process supporting the emerging adult self.
- dc.format.mimetype application/pdf
- dc.identifier.citation Davey CG, Fornito A, Pujol J, Breakspear M, Schmaal L, Harrison BJ. Neurodevelopmental correlates of the emerging adult self. Dev Cogn Neurosci. 2019 Apr;36:100626. DOI 10.1016/j.dcn.2019.100626
- dc.identifier.doi http://dx.doi.org/10.1016/j.dcn.2019.100626
- dc.identifier.issn 1878-9293
- dc.identifier.uri http://hdl.handle.net/10230/43054
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights 1878-9293/ © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
- dc.subject.keyword Adolescent development
- dc.subject.keyword Connectivity
- dc.subject.keyword Default mode network
- dc.subject.keyword Functional MRI
- dc.subject.keyword Self
- dc.title Neurodevelopmental correlates of the emerging adult self
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion