Auricular transcutaneous vagus nerve stimulation acutely modulates brain connectivity in mice.
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Brambilla Pisoni, Cecilia, 1993-
- dc.contributor.author Muñoz-Moreno, Emma
- dc.contributor.author Gallego-Amaro, Ianire
- dc.contributor.author Maldonado, Rafael, 1961-
- dc.contributor.author Ivorra Cano, Antoni, 1974-
- dc.contributor.author Soria Rodríguez, Guadalupe
- dc.contributor.author Ozaita Mintegui, Andrés, 1969-
- dc.date.accessioned 2022-06-21T06:09:29Z
- dc.date.available 2022-06-21T06:09:29Z
- dc.date.issued 2022
- dc.description.abstract Brain electrical stimulation techniques take advantage of the intrinsic plasticity of the nervous system, opening a wide range of therapeutic applications. Vagus nerve stimulation (VNS) is an approved adjuvant for drug-resistant epilepsy and depression. Its non-invasive form, auricular transcutaneous VNS (atVNS), is under investigation for applications, including cognitive improvement. We aimed to study the effects of atVNS on brain connectivity, under conditions that improved memory persistence in CD-1 male mice. Acute atVNS in the cymba conchae of the left ear was performed using a standard stimulation protocol under light isoflurane anesthesia, immediately or 3 h after the training/familiarization phase of the novel object-recognition memory test (NORT). Another cohort of mice was used for bilateral c-Fos analysis after atVNS administration. Spearman correlation of c-Fos density between each pair of the thirty brain regions analyzed allowed obtaining the network of significant functional connections in stimulated and non-stimulated control brains. NORT performance was enhanced when atVNS was delivered just after, but not 3 h after, the familiarization phase of the task. No alterations in c-Fos density were associated with electrostimulation, but a significant effect of atVNS was observed on c-Fos-based functional connectivity. atVNS induced a clear reorganization of the network, increasing the inter-hemisphere connections and the connectivity of locus coeruleus. Our results provide new insights into the effects of atVNS on memory performance and brain connectivity extending our knowledge of the biological mechanisms of bioelectronics in medicine.
- dc.description.sponsorship The project that gave rise to these results received the support of a fellowship from la Caixa Foundation (ID 100010434). The fellowship code is LCF/BQ/IN18/11660012 (CB-P). This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Slodowska-Curie grant agreement No. 713673. This work was supported by the Ministerio de Economía, Innovación y Competitividad (MINECO) (#RTI2018-099282-B-I00 to AO and PID2020-120029GB-I00/MICIN/AEI/10.13039/501100011033 to RM); the Instituto de Salud Carlos III (#RD16/0017/0020 to RM and PI18/00893 cofunded by ERDF A way to make Europe to GS); the Generalitat de Catalunya (2017SGR-669 to RM); the ICREA (Institució Catalana de Recerca i Estudis Avançats) Academia to AO, AI, and RM; Grant Unidad de Excelencia María de Maeztu, funded by the MINECO (#MDM-2014-0370); and PLAN E (Plan Español para el Estímulo de la Economía y el Empleo). FEDER funding is also acknowledged.
- dc.format.mimetype application/pdf
- dc.identifier.citation Brambilla-Pisoni C, Muñoz-Moreno E, Gallego-Amaro I, Maldonado R, Ivorra A, Soria G, Ozaita A. Auricular transcutaneous vagus nerve stimulation acutely modulates brain connectivity in mice. Front Cell Neurosci. 2022 Apr 25;16:856855. DOI: 10.3389/fncel.2022.856855
- dc.identifier.doi http://dx.doi.org/10.3389/fncel.2022.856855
- dc.identifier.issn 1662-5102
- dc.identifier.uri http://hdl.handle.net/10230/53544
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Front Cell Neurosci. 2022 Apr 25;16:856855
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/713673
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-099282-B-I00
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-120029GB-I00
- dc.rights © 2022 Brambilla-Pisoni, Muñoz-Moreno, Gallego-Amaro, Maldonado, Ivorra, Soria and Ozaita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Auricular transcutaneous vagus nerve stimulation
- dc.subject.keyword Brain connectivity
- dc.subject.keyword c-Fos functional networks
- dc.subject.keyword Electrostimulation
- dc.subject.keyword Memory persistence
- dc.title Auricular transcutaneous vagus nerve stimulation acutely modulates brain connectivity in mice.
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion