Childhood exposure to outdoor air pollution in different microenvironments and cognitive and fine motor function in children from six European cohorts

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• dc.contributor.author Domínguez, Alan
• dc.contributor.author Koch, Sarah
• dc.contributor.author Márquez, Sandra
• dc.contributor.author Castro, Montserrat de
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Evandt, Jorunn
• dc.contributor.author Oftedal, Bente
• dc.contributor.author Aasvang, Gunn Marit
• dc.contributor.author Kampouri, Mariza
• dc.contributor.author Vafeiadi, Marina, 1983-
• dc.contributor.author Mon-Williams, Mark
• dc.contributor.author Lewer, Dan
• dc.contributor.author Lepeule, Johanna
• dc.contributor.author Andrušaitytė, Sandra
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.date.accessioned 2024-09-03T14:26:10Z
• dc.date.embargoEnd info:eu-repo/date/embargoEnd/2026-01-19
• dc.date.issued 2024
• dc.description.abstract Background: Exposure to air pollution during childhood has been linked with adverse effects on cognitive development and motor function. However, limited research has been done on the associations of air pollution exposure in different microenvironments such as home, school, or while commuting with these outcomes. Objective: To analyze the association between childhood air pollution exposure in different microenvironments and cognitive and fine motor function from six European birth cohorts. Methods: We included 1301 children from six European birth cohorts aged 6-11 years from the HELIX project. Average outdoor air pollutants concentrations (NO2, PM2.5) were estimated using land use regression models for different microenvironments (home, school, and commute), for 1-year before the outcome assessment. Attentional function, cognitive flexibility, non-verbal intelligence, and fine motor function were assessed using the Attention Network Test, Trail Making Test A and B, Raven Colored Progressive Matrices test, and the Finger Tapping test, respectively. Adjusted linear regressions models were run to determine the association between each air pollutant from each microenvironment on each outcome. Results: In pooled analysis we observed high correlation (rs = 0.9) between air pollution exposures levels at home and school. However, the cohort-by-cohort analysis revealed correlations ranging from low to moderate. Air pollution exposure levels while commuting were higher than at home or school. Exposure to air pollution in the different microenvironments was not associated with working memory, attentional function, non-verbal intelligence, and fine motor function. Results remained consistently null in random-effects meta-analysis. Conclusions: No association was observed between outdoor air pollution exposure in different microenvironments (home, school, commute) and cognitive and fine motor function in children from six European birth cohorts. Future research should include a more detailed exposure assessment, considering personal measurements and time spent in different microenvironments.
• dc.description.sponsorship This publication reflects only the author's views and the European Commission is not liable for any use that may be made of the information contained. The study received funding from the European Community's Seventh Framework Programme (FP7/2007–206) (grant agreement no 308333) (HELIX project), the H2020-EU.3.1.2. - Preventing Disease Programme (grant agreement no 874583) (ATHLETE project) and from the Euro-pean Union's Horizon 2020 research and innovation programme (grant Agreement number: 733,206) (Early Life stressors and Lifecycle Health (LIFECYCLE)). BiB received funding from the Welcome Trust (WT101597MA), from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1), and the National Institute for Health Research (NIHR) Applied Research Collaboration for Yorkshire and Humber. The EDEN study was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte sant; e 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestle, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (FP7/2007–2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes Na-tional Research Program (through a collaboration with the French As- sociation of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Generale de l’Education Nationale a complementary health insurance (MGEN), French national agency for food security, French-speaking association for the study of diabetes and metabolism (ALFEDIAM). INMA was supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Cata-lunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Nor-wegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV. 2007.1.2.2.2. Project No 211250 Escape, EU FP7-, 2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV. 2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), and the Greek Ministry of Health (Program of Prevention of obesity and neu-rodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). Mònica Guxens is funded by a Miguel Servet II fellowship (CPII18/00018) awarded by the Spanish Institute of Health Carlos III. The Barcelona Institute for Global Health (ISGlobal) is a member of the Agency for the Research Centres of Catalonia (CERCA) Programme, Generalitat de Catalunya. Jose Urquiza is supported by Catalan program PERIS (Ref.: SLT017/20/000119), granted by Departament de Salut de la Generalitat de Catalunya (Spain). We are grateful to all the participating children, parents, practitioners and researchers in the six countries participating in this study.
• dc.embargo.liftdate 2026-01-19
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez A, Koch S, Marquez S, Castro M, Urquiza J, Evandt J, et al. Childhood exposure to outdoor air pollution in different microenvironments and cognitive and fine motor function in children from six European cohorts. Environ Res. 2024 Apr 15;247:118174. DOI: 10.1016/j.envres.2024.118174
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2024.118174
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/60996
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Res. 2024 Apr 15;247:118174
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.envres.2024.118174
• dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
• dc.subject.keyword Air pollution
• dc.subject.keyword Childhood
• dc.subject.keyword Cognitive function
• dc.subject.keyword Fine motor function
• dc.subject.keyword Long-term effects
• dc.subject.keyword Microenvironments
• dc.title Childhood exposure to outdoor air pollution in different microenvironments and cognitive and fine motor function in children from six European cohorts
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion