The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

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  • dc.contributor.author Casas Sanahuja, Maribel
  • dc.contributor.author den Dekker, Herman T.
  • dc.contributor.author Kruithof, Claudia J.
  • dc.contributor.author Reiss, Irwin K.
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Jongste, Johan C. de
  • dc.contributor.author Jaddoe, Vincent W. V.
  • dc.contributor.author Duijts, Liesbeth
  • dc.date.accessioned 2019-07-26T07:34:23Z
  • dc.date.available 2019-07-26T07:34:23Z
  • dc.date.issued 2018
  • dc.description.abstract Background: Infant weight gain is associated with lower lung function and a higher risk of childhood asthma. Detailed individual childhood growth patterns might be better predictors of childhood respiratory morbidity than the difference between two weight and height measurements. We assessed the associations of early childhood growth patterns with lung function and asthma at the age of 10 years and whether the child’s current body mass index (BMI) influenced any association. Methods: We derived peak height and weight growth velocity, BMI at adiposity peak, and age at adiposity peak from longitudinally measured weight and height data in the first 3 years of life of 4435 children enrolled in a population-based prospective cohort study. At 10 years of age, spirometry was performed and current asthma was assessed by questionnaire. Spirometry outcomes included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, and forced expiratory flow after exhaling 75% of vital capacity (FEF75). Results: Greater peak weight velocity was associated with higher FVC but lower FEV1/FVC and FEF75. Greater BMI at adiposity peak was associated with higher FVC and FEV1 but lower FEV1/FVC and FEF75. Greater age at adiposity peak was associated with higher FVC, FEV1, FEV1/FVC and FEF75, particularly in children with a small size at birth, and lower odds of current asthma in boys. The child’s current BMI only explained the associations of peak weight velocity and BMI at adiposity peak with FVC and FEV1. Peak height velocity was not consistently associated with impaired lung function or asthma. Conclusion: Peak weight velocity and BMI at adiposity peak were associated with reduced airway patency in relation to lung volume, whereas age at adiposity peak was associated with higher lung function parameters and lower risk of asthma at 10 years, particularly in boys.
  • dc.description.sponsorship The Generation R Study is made possible by financial support from the Erasmus Medical Centre, Rotterdam, Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. Dr Liesbeth Duijts received additional funding from the European Union’s Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) (ALPHABET project (no. 696295; 2017), ZonMW The Netherlands (no. 529051014; 2017)). The study was supported by the Netherlands Organization for Health Research and Development (VIDI 016.136.361), a European Research Council Consolidator Grant (ERC-2014-CoG-648916), funding from the European Union’s Seventh Framework Programme under grant agreement no. 289346 (EarlyNutrition), and funding from the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 733206 (LifeCycle) and no. 633595 (DynaHEALTH). Dr Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128). The researchers are independent from the funders.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Casas M, den Dekker HT, Kruithof CJ, Reiss IK, Vrijheid M, Sunyer J, Jongste JC de, Jaddoe VWV, Duijts L. The effect of early growth patterns and lung function on the development of childhood asthma: a population based study. Thorax. 2018;73(12):1137-45. DOI: 10.1136/thoraxjnl-2017-211216
  • dc.identifier.doi http://dx.doi.org/10.1136/thoraxjnl-2017-211216
  • dc.identifier.issn 0040-6376
  • dc.identifier.uri http://hdl.handle.net/10230/42184
  • dc.language.iso eng
  • dc.publisher BMJ Publishing Group
  • dc.relation.ispartof Thorax. 2018;73(12):1137-45
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289346
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/696295
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633595
  • dc.rights © BMJ Publishing Group https://thorax.bmj.com/content/73/12/1137
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Asthma
  • dc.subject.keyword Paediatric asthma
  • dc.title The effect of early growth patterns and lung function on the development of childhood asthma: a population based study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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