Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain

Karachaliou, Marianna; Moncunill, Gemma; Espinosa Díaz, Ana; Castaño Vinyals, Gemma; Jiménez, Alfons; Vidal, Marta; Santano, Rebeca; Barrios, Diana; Puyol, Laura; Mayer, Leonie; Rubio, Rocío; O'Callaghan-Gordo, Cristina; Fossati, Serena; Rivas, Ioar; Vrijheid, Martine; Izquierdo, Luis; Aguilar, Ruth; Basagaña Flores, Xavier; García Aymerich, Judith; Dobaño, Carlota; Kogevinas, Manolis

Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain

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dc.contributor.author Karachaliou, Marianna
dc.contributor.author Moncunill, Gemma
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Jiménez, Alfons
dc.contributor.author Vidal, Marta
dc.contributor.author Santano, Rebeca
dc.contributor.author Barrios, Diana
dc.contributor.author Jiménez, Alfons
dc.contributor.author Puyol, Laura
dc.contributor.author Mayer, Leonie
dc.contributor.author Rubio, Rocío
dc.contributor.author O'Callaghan-Gordo, Cristina
dc.contributor.author Fossati, Serena
dc.contributor.author Rivas, Ioar
dc.contributor.author Vrijheid, Martine
dc.contributor.author Izquierdo, Luis
dc.contributor.author Aguilar, Ruth
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author García Aymerich, Judith
dc.contributor.author Dobaño, Carlota
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2022-06-02T06:02:42Z
dc.date.available 2022-06-02T06:02:42Z
dc.date.issued 2021
dc.description.abstract Sparse data exist on the complex natural immunity to SARS-CoV-2 at the population level. We applied a well-validated multiplex serology test in 5000 participants of a general population study in Catalonia in blood samples collected from end June to mid November 2020. Based on responses to fifteen isotype-antigen combinations, we detected a seroprevalence of 18.1% in adults (n = 4740), and modeled extrapolation to the general population of Catalonia indicated a 15.3% seroprevalence. Antibodies persisted up to 9 months after infection. Immune profiling of infected individuals revealed that with increasing severity of infection (asymptomatic, 1-3 symptoms, ≥ 4 symptoms, admitted to hospital/ICU), seroresponses were more robust and rich with a shift towards IgG over IgA and anti-spike over anti-nucleocapsid responses. Among seropositive participants, lower antibody levels were observed for those ≥ 60 years vs < 60 years old and smokers vs non-smokers. Overweight/obese participants vs normal weight had higher antibody levels. Adolescents (13-15 years old) (n = 260) showed a seroprevalence of 11.5%, were less likely to be tested seropositive compared to their parents and had dominant anti-spike rather than anti-nucleocapsid IgG responses. Our study provides an unbiased estimate of SARS-CoV-2 seroprevalence in Catalonia and new evidence on the durability and heterogeneity of post-infection immunity.
dc.description.sponsorship We thank the volunteers who participate in the cohort studies, all the workers in different facilities of the Blood and Tissue Bank for sample recruitment, Jordi Chi for antigen expression and purification and Victor Moreno for data collection in MCC study. This study makes use of data generated by the GCAT-Genomes for Life. Cohort study of the Genomes of Catalonia, Fundacio IGTP. IGTP is part of the CERCA Program/Generalitat de Catalunya. GCAT is supported by Acción de Dinamización del ISCIII-MINECO and the Ministry of Health of the Generalitat of Catalunya (ADE 10/00026); the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2017-SGR 529). Full list of the investigators who contributed to the generation of the GCAT data is available from www.genomesforlife.com. LeRAgs is supported by Instituto de Salud Carlos III (PI17/01555). Beatriz Cortés is supported by ISCIII national Grant PI18/01512. Ioar Rivas is supported from the postdoctoral fellowships programme Beatriu de Pinós (2018 BP 00114), funded by the Secretary of Universities and Research (Government of Catalonia) and by the Horizon 2020 programme of research and innovation of the European Union under the Marie Sklodowska-Curie Grant Agreement No 801370. This work was funded by Incentius a l’Avaluació de Centres CERCA (in_CERCA); EIT HEALTH BP2020-20873-Certify.Health.; Fundació Privada Daniel Bravo Andreu; PID2019-110810RB-I00 Grant (Spanish Ministry of Science & Innovation). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S). ISGlobal and IGTP receive support from the Generalitat de Catalunya through the CERCA Program. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
dc.format.mimetype application/pdf
dc.identifier.citation Karachaliou M, Moncunill G, Espinosa A, Castaño-Vinyals G, Jiménez A, Vidal M, et al. Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain. Sci Rep. 2021 Nov 3;11(1):21571. DOI: 10.1038/s41598-021-00807-4
dc.identifier.doi http://dx.doi.org/10.1038/s41598-021-00807-4
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/53358
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2021 Nov 3;11(1):21571
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/801370
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110810RB-I00
dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Epidemiology
dc.subject.keyword Risk factors
dc.subject.keyword Viral infection
dc.title Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
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