Exposure to outdoor residential noise during pregnancy, embryonic size, fetal growth, and birth outcomes

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• dc.contributor.author Graafland, Naomi
• dc.contributor.author Essers, Esmée
• dc.contributor.author Posthumus, Anke
• dc.contributor.author Gootjes, Dionne
• dc.contributor.author Ambrós, Albert
• dc.contributor.author Steegers, Eric
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2023-03-13T11:45:07Z
• dc.date.available 2023-03-13T11:45:07Z
• dc.date.issued 2023
• dc.description Includes supplementary materials for the online appendix.
• dc.description.abstract Previous literature suggested that noise exposure during pregnancy was not associated with adverse birth outcomes. However, no studies evaluated the association between noise exposure and embryonic and fetal growth, or mutually assessed other urban environmental exposures such as traffic-related air pollution or natural spaces. We included 7947 pregnant women from the Generation R Study, the Netherlands. We estimated total (road traffic, aircraft, railway, and industry), road traffic, and railway noise at the participants' home addresses during pregnancy using environmental noise maps. We estimated traffic-related air pollution using land-use regression models, greenness within a 300 m buffer using the normalized difference vegetation index, and distance to blue spaces using topographical maps at the home addresses. Embryonic size (crown-rump length) and fetal growth parameters (head circumference, femur length, and estimated fetal weight) were measured by ultrasound at several gestational ages. Information on neonatal anthropometrics at birth (head circumference, length, and weight) and adverse birth outcomes (preterm birth, low birth weight, and small for gestational age) were retrieved from medical records. Higher total noise exposure during pregnancy was associated with larger crown-rump length (0.07 SDS [95%CI 0.00 to 0.14]). No association was found with fetal growth parameters, neonatal anthropometrics, and adverse birth outcomes. Similar results were observed for road traffic noise exposure, while railway noise exposure was not associated with any of the outcomes. Traffic-related air pollution was not associated with crown-rump length. Total noise exposure mediated 15% of the association between exposure to greenness and smaller crown-rump length. No association was observed between distance to blue spaces and total noise exposure. Exposure to outdoor residential noise during pregnancy was associated with larger embryonic size. Moreover, a reduction of total noise exposure during pregnancy partially mediated the association between exposure to greenness and smaller embryonic size. Additional research is warranted to confirm and further understand these novel findings.
• dc.description.sponsorship The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. We gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives and pharmacies in Rotterdam. The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development (ZonMw), the Netherlands Organization for Scientific Research (NWO), and the Ministry of Health, Welfare and Sport. Mònica Guxens received funding from the Spanish Institute of Health Carlos III (PI17/01340 including FEDER funds, CPII18/00018). We thank DCMR Milieudienst Rijnmond for providing the noise data. The geocodification of the addresses of the Dutch study participants was done within the framework of a project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. Esmée Essers was funded by the EU commission via a fellowship within the LifeCycle Project (733206) and by the Agence Nationale de Securité de Sanitaire de l’Alimentation de l’Environnement et du Travail (EST-18 RF-25).
• dc.format.mimetype application/pdf
• dc.identifier.citation Graafland N, Essers E, Posthumus A, Gootjes D, Ambrós A, Steegers E, et al. Exposure to outdoor residential noise during pregnancy, embryonic size, fetal growth, and birth outcomes. Environment International. 2023 Jan;171:107730. DOI: 10.1016/j.envint.2023.107730
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2023.107730
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/56192
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environment International. 2023 Jan;171:107730
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/2PE/CEX2018-000806-S
• dc.rights © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Environmental pollution
• dc.subject.keyword Development
• dc.subject.keyword Cohort study
• dc.subject.keyword Pregnancy
• dc.subject.keyword Road traffic noise
• dc.title Exposure to outdoor residential noise during pregnancy, embryonic size, fetal growth, and birth outcomes
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion