​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs

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  • dc.contributor.author Moon, Katherine L.
  • dc.contributor.author Huson, Heather J.
  • dc.contributor.author Morrill, Kathleen
  • dc.contributor.author Wang, Ming-Shan
  • dc.contributor.author Li, Xue
  • dc.contributor.author Srikanth, Krishnamoorthy
  • dc.contributor.author Zoonomia Consortium
  • dc.contributor.author Lindblad-Toh, Kerstin
  • dc.contributor.author Svenson, Gavin J.
  • dc.contributor.author Karlsson, Elinor K.
  • dc.contributor.author Shapiro, Beth
  • dc.date.accessioned 2024-03-27T08:13:07Z
  • dc.date.available 2024-03-27T08:13:07Z
  • dc.date.issued 2023
  • dc.description.abstract We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat features atypical for modern sled dog breeds, and a slightly smaller stature. He had enhanced starch digestion compared with Greenland sled dogs and a compendium of derived homozygous coding variants at constrained positions in genes connected to bone and skin development. We propose that Balto's population of origin, which was less inbred and genetically healthier than that of modern breeds, was adapted to the extreme environment of 1920s Alaska.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Moon KL, Huson HJ, Morrill K, Wang MS, Li X, Srikanth K, et al. ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs. Science. 2023 Apr 28;380(6643):eabn5887. DOI: 10.1126/science.abn5887
  • dc.identifier.doi http://dx.doi.org/10.1126/science.abn5887
  • dc.identifier.issn 0036-8075
  • dc.identifier.uri http://hdl.handle.net/10230/59592
  • dc.language.iso eng
  • dc.publisher American Association for the Advancement of Science (AAAS)
  • dc.relation.ispartof Science. 2023 Apr 28;380(6643):eabn5887
  • dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science. 2023 Apr 28;380(6643):eabn5887, DOI: 10.1126/science.abn5887.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Genòmica comparativa
  • dc.title ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Center for Genomic Regulation (CRG))