Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study
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- dc.contributor.author Ballvé, Alejandro
- dc.contributor.author Pizarro, Jesús
- dc.contributor.author Maisterra, Olga
- dc.contributor.author Riba Llena, Iolanda
- dc.contributor.author Pujadas, Francesc
- dc.contributor.author Jiménez-Balado, Joan
- dc.contributor.author Palasi, Antonio
- dc.contributor.author Cirach, Marta
- dc.contributor.author Turner, Michelle C.
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Delgado, Pilar
- dc.date.accessioned 2024-11-15T07:15:19Z
- dc.date.available 2024-11-15T07:15:19Z
- dc.date.issued 2024
- dc.description.abstract Background and purpose: Although air pollution (AP) has been associated with stroke and dementia, data regarding its relationship with covert cerebrovascular disease (cCVD) and cognition over time are sparse. The aim of this study was to explore these relationships. Methods: A prospective population-based study of 976 stroke-free and non-demented individuals living in Barcelona, Spain, was conducted during 2010-2016. A land use regression model was used to estimate the exposure of each participant to AP: NOx, NO2, PM2.5, PM10, PMcoarse and PM2.5 absorbance. Cognitive function and cCVD were assessed at baseline (n = 976) and 4 years after (n = 317). Multivariate-adjusted models were developed. Results: At baseline, 99 participants (10.1%) had covert brain infarcts and 91 (9.3%) had extensive periventricular white matter hyperintensities (WMHs). Marked subcortical WMH progression was seen in 19.7%; the incidence of other covert cerebrovascular lessons ranged between 5% and 6% each. PM2.5 was related to higher odds of having a covert brain infarct (odds ratio [OR] 2.21; 95% confidence interval [CI] 1.06-4.60). PM2.5 absorbance was related to higher odds of having extensive subcortical WMHs (OR 1.72; 95% CI 1.13-2.60), whereas NO2 was related to higher odds of having extensive subcortical (OR 1.66; 95% CI 1.17-2.35) or periventricular (OR 1.96; 95% CI 1.10-3.50) WMHs and to higher odds of developing marked subcortical WMH progression (OR 1.40; 95% CI 1.05-1.90). NOx was related to incident cerebral microbleeds (OR 1.36; 95% CI 1.04-1.79). There was no association between AP and cognition. Conclusions: Air pollutant predicts the presence and accumulation of cCVD. Its impact on cognitive impairment remains to be determined.
- dc.format.mimetype application/pdf
- dc.identifier.citation Ballvé A, Pizarro J, Maisterra O, Riba-Llena I, Pujadas F, Jiménez-Balado J, et al. Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study. Eur J Neurol. 2024 Oct;31(10):e16404. DOI: 10.1111/ene.16404
- dc.identifier.doi http://dx.doi.org/10.1111/ene.16404
- dc.identifier.issn 1351-5101
- dc.identifier.uri http://hdl.handle.net/10230/68704
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Eur J Neurol. 2024 Oct;31(10):e16404
- dc.rights © 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Air pollution
- dc.subject.keyword Brain infarction
- dc.subject.keyword Cerebrovascular disorders
- dc.subject.keyword Cognitive impairment
- dc.subject.keyword Particulate matter
- dc.title Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion