Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome

Ruiz Limón, Patricia; Muralidharan, Jananee; Gómez Pérez, Ana María; Murri, Mora; Vioque, Jesus; Corella, Dolores; Fitó Colomer, Montserrat; Vidal, Josep; Salas-Salvadó, Jordi; Torres-Collado, Laura; Coltell, Oscar; Atzeni, Alessandro; Castañer, Olga; Bulló, Mònica; Bernal López, María Rosa; Moreno-Indias, Isabel; Tinahones Madueño, Francisco José

Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome

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dc.contributor.author Ruiz Limón, Patricia
dc.contributor.author Muralidharan, Jananee
dc.contributor.author Gómez Pérez, Ana María
dc.contributor.author Murri, Mora
dc.contributor.author Vioque, Jesus
dc.contributor.author Corella, Dolores
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Vidal, Josep
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author Torres-Collado, Laura
dc.contributor.author Coltell, Oscar
dc.contributor.author Atzeni, Alessandro
dc.contributor.author Castañer, Olga
dc.contributor.author Bulló, Mònica
dc.contributor.author Bernal López, María Rosa
dc.contributor.author Moreno-Indias, Isabel
dc.contributor.author Tinahones Madueño, Francisco José
dc.date.accessioned 2025-10-17T16:44:11Z
dc.date.available 2025-10-17T16:44:11Z
dc.date.issued 2024
dc.date.updated 2025-10-17T16:44:10Z
dc.description.abstract We aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED-Plus study with 152 males and 145 females with overweight/obesity and metabolic syndrome. General assessments, anthropometric and biochemical measurements, and gut microbial 16S rRNA sequencing data were analyzed at baseline and 1-year of follow-up. Participants were stratified by tertiles of 1-year change in total PA-related energy expenditure ranging from -98.77 to 1099.99 METs (min/week). The total PA percentage of change was reduced in tertile 1 (-44.83 ± 24.94), increased in tertile 2 (28.96 ± 23.33) and tertile 3 (273.64 ± 221.42). Beta diversity analysis showed differences in the gut microbiota population within each tertile group. Significant differences were found at phylum, family, and genus levels in the gut microbiota of the three tertile groups at baseline and 1-year timepoint. Tertile 3, the group with the greatest increase in PA, was characterized by increases in their levels of Sutterella, Bilophila, and Lachnospira bacteria as well as a reduction in Collinsella. Moreover, this tertile showed a different pattern in its predicted metabolic capacities to the other groups. Our results have demonstrated that changes in PA such as lifestyle and Mediterranean diet induces specific variations in the gut microbiota profile. This modulation of gut microbiome populations and their metabolic capacities may contribute to the health of the aged individuals with overweight/obesity and metabolic syndrome.
dc.description.sponsorship This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (three coordinated FIS projects lead by JS-S: PI13/00462, PI16/00501 and PI19/00576; two led by JV: PI17/01441, PI14/01206; and two led by MRBL: PI14/00696 and PI17/00855); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant (OBN16PE01) to JS-S; the Recercaixa (number 2013ACUP00194) grant to JS-S. DC obtained grant from the Generalitat Valenciana (PROMETEO 2017/17) and Grant from the Ministry of Science and Innovation/Instituto de Salud Carlos III (reference: PI19/00781). Eat2beNICE project (European Union's Horizon 2020 research and innovation programme under grant agreement No 728018). PRL was supported by a "Sara Borrell" postdoctoral contract (CD19/00216) from the ISCIII-Madrid (Spain), co-financed by the Fondo Europeo de Desarrollo Regional-(FEDER). IMI was supported by the "Miguel Servet Type II" program (CPII21/00013) of the ISCIII-Madrid (Spain), co-financed by the FEDER. JM and AA were supported by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 713679, cofunded from the Universitat Rovira i Virgili (URV) and Fundació Catalunya La Pedrera. OCN was supported by Juan Rodés program JR17/00022 and PI20/00012. MM is supported by Miguel Servet I program (CP17/00133) from ISCIII and cofunded by FEDER. AMGP was supported by a research contract from Servicio Andaluz de Salud (B-0033-2014). MRBL is supported by Miguel Servet II program (CPII/00014) from ISCIII and by Nicolás Monardes program (C1-0005-2020) from Servicio Andaluz de Salud, both cofunded by FEDER. This work is partially supported by ICREA. Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil; and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Pilot study.
dc.format.mimetype application/pdf
dc.identifier.citation Ruiz-Limón P, Muralidharan J, Gomez-Perez AM, Murri M, Vioque J, Corella D, Fitó M, Vidal J, Salas-Salvadó J, Torres-Collado L, Coltell O, Atzeni A, Castañer O, Bulló M, Bernal-López MR, Moreno-Indias I, Tinahones FJ. Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome. Biol Sport. 2024 Jul;41(3):47-60. DOI: 10.5114/biolsport.2024.133005
dc.identifier.doi http://dx.doi.org/10.5114/biolsport.2024.133005
dc.identifier.issn 0860-021X
dc.identifier.uri http://hdl.handle.net/10230/71541
dc.language.iso eng
dc.publisher Termedia Publishing
dc.relation.ispartof Biology of Sport. 2024;41(3):47-60
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/728018
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/713679
dc.rights Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/). This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Gut microbiota
dc.subject.keyword Metabolic syndrome
dc.subject.keyword Obesity
dc.subject.keyword Overweight
dc.subject.keyword Physical activity
dc.title Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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