Molecular and cellular reorganization of neural circuits in the human lineage

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• dc.contributor.author Sousa, André M. M.
• dc.contributor.author Zhu, Ying
• dc.contributor.author Raghanti, Mary Ann
• dc.contributor.author Kitchen, Robert R.
• dc.contributor.author Onorati, Marco
• dc.contributor.author Tebbenkamp, Andrew T. N.
• dc.contributor.author Stutz, Bernardo
• dc.contributor.author Meyer, Kyle A.
• dc.contributor.author Li, Mingfeng
• dc.contributor.author Kawasawa, Yuka Imamura
• dc.contributor.author Liu, Fuchen
• dc.contributor.author García Pérez, Raquel, 1989-
• dc.contributor.author Mele, Marta
• dc.contributor.author Carvalho, Tiago Loureiro de, 1987-
• dc.contributor.author Skarica, Mario
• dc.contributor.author Gulden, Forrest O.
• dc.contributor.author Pletikos, Mihovil
• dc.contributor.author Shibata, Akemi
• dc.contributor.author Stephenson, Alexa R.
• dc.contributor.author Edler, Melissa K.
• dc.contributor.author Ely, John J.
• dc.contributor.author Elsworth, John D.
• dc.contributor.author Horvath, Tamas L.
• dc.contributor.author Hof, Patrick R.
• dc.contributor.author Hyde, Thomas M.
• dc.contributor.author Kleinman, Joel E.
• dc.contributor.author Weinberger, Daniel R.
• dc.contributor.author Reimers, Mark
• dc.contributor.author Lifton, Richard P.
• dc.contributor.author Mane, Shrikant M.
• dc.contributor.author Noonan, James P.
• dc.contributor.author State, Matthew W.
• dc.contributor.author Lein, Ed S.
• dc.contributor.author Knowles, James A.
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.contributor.author Sherwood, Chet C.
• dc.contributor.author Gerstein, Mark B.
• dc.contributor.author Sestan, Nenad
• dc.date.accessioned 2018-11-13T09:57:08Z
• dc.date.available 2018-11-13T09:57:08Z
• dc.date.issued 2017
• dc.description.abstract To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type-specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.
• dc.description.sponsorship Data was generated as part of the PsychENCODE Consortium, supported by MH103339, MH106934, and MH110926. Additional support was provided by the NIH grant MH109904, the Kavli Foundation, the James S. McDonnell Foundation, NSF grant BCS-1316829, and ERC Starting Grant 260372, and MICINN BFU2011-28549
• dc.format.mimetype application/pdf
• dc.identifier.citation Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN et al. Molecular and cellular reorganization of neural circuits in the human lineage. Science. 2017 Nov 24;358(6366):1027-32. DOI: 10.1126/science.aan3456
• dc.identifier.doi http://dx.doi.org/10.1126/science.aan3456
• dc.identifier.issn 0036-8075
• dc.identifier.uri http://hdl.handle.net/10230/35740
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science. 2017 Nov 24;358(6366):1027-32
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
• dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 2017 Nov 24, v. 358, n. 6366, DOI: 10.1126/science.aan3456
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Cercopitècids
• dc.subject.other Escorça cerebral
• dc.subject.other Sistema nerviós
• dc.subject.other Ximpanzé comú
• dc.subject.other Transcriptomes
• dc.title Molecular and cellular reorganization of neural circuits in the human lineage
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion