Global genetic diversity of human gut microbiome species is related to geographic location and host health
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- dc.contributor.author Andreu-Sánchez, Sergio
- dc.contributor.author Blanco-Míguez, Aitor
- dc.contributor.author Wang, Daoming
- dc.contributor.author Golzato, Davide
- dc.contributor.author Manghi, Paolo
- dc.contributor.author Heidrich, Vitor
- dc.contributor.author Fackelmann, Gloria
- dc.contributor.author Zhernakova, Daria V.
- dc.contributor.author Kurilshikov, Alexander
- dc.contributor.author Vallès Colomer, Mireia
- dc.contributor.author Weersma, Rinse K.
- dc.contributor.author Zhernakova, Alexandra
- dc.contributor.author Fu, Jingyuan
- dc.contributor.author Segata, Nicola
- dc.date.accessioned 2025-06-13T07:46:36Z
- dc.date.available 2025-06-13T07:46:36Z
- dc.date.issued 2025
- dc.description Data de publicació electrònica: 30-04-2025
- dc.description.abstract The human gut harbors thousands of microbial species, each exhibiting significant inter-individual genetic variability. Although many studies have associated microbial relative abundances with human-health-related phenotypes, the substantial intraspecies genetic variability of gut microbes has not yet been comprehensively considered, limiting the potential of linking such genetic traits with host conditions. Here, we analyzed 32,152 metagenomes from 94 microbiome studies across the globe to investigate the human microbiome intraspecies genetic diversity. We reconstructed 583 species-specific phylogenies and linked them to geographic information and species' horizontal transmissibility. We identified 484 microbial-strain-level associations with 241 host phenotypes, encompassing human anthropometric factors, biochemical measurements, diseases, and lifestyle. We observed a higher prevalence of a Ruminococcus gnavus clade in nonagenarians correlated with distinct plasma bile acid profiles and a melanoma and prostate-cancer-associated Collinsella clade. Our large-scale intraspecies genetic analysis highlights the relevance of strain diversity as it relates to human health.
- dc.format.mimetype application/pdf
- dc.identifier.citation Andreu-Sánchez S, Blanco-Míguez A, Wang D, Golzato D, Manghi P, Heidrich V, et al. Global genetic diversity of human gut microbiome species is related to geographic location and host health. Cell. 2025 Apr 30:S0092-8674(25)00416-7. DOI: 10.1016/j.cell.2025.04.014
- dc.identifier.doi http://dx.doi.org/10.1016/j.cell.2025.04.014
- dc.identifier.issn 0092-8674
- dc.identifier.uri http://hdl.handle.net/10230/70680
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cell. 2025 Apr 30:S0092-8674(25)00416-7
- dc.rights © 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Aging
- dc.subject.keyword Bacterial phylogenetics
- dc.subject.keyword Biogeography
- dc.subject.keyword Cancer
- dc.subject.keyword Human gut microbiome
- dc.subject.keyword Metagenomics
- dc.subject.keyword Microbial strains
- dc.title Global genetic diversity of human gut microbiome species is related to geographic location and host health
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion